Homo sapiens Gene: DPEP1
Summary
InnateDB Gene IDBG-47798.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPEP1
Gene Name dipeptidase 1 (renal)
Synonyms MBD1; MDP; RDP;
Species Homo sapiens
Ensembl Gene ENSG00000015413
Encoded Proteins
dipeptidase 1 (renal)
dipeptidase 1 (renal)
dipeptidase 1 (renal)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:89613308-89638456
Strand Forward strand
Band q24.3
Transcripts
ENST00000261615 ENSP00000261615
ENST00000393092 ENSP00000376807
ENST00000421184 ENSP00000397313
ENST00000570029 ENSP00000455916
ENST00000568281 ENSP00000455142
ENST00000564645
ENST00000561484
ENST00000565249
ENST00000564281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008235 metalloexopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
GO:0016805 dipeptidase activity
GO:0034235 GPI anchor binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872 metal ion binding
GO:0070573 metallodipeptidase activity
GO:0072341 modified amino acid binding
Biological Process
GO:0006508 proteolysis
GO:0006691 leukotriene metabolic process
GO:0006749 glutathione metabolic process
GO:0016999 antibiotic metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0030336 negative regulation of cell migration
GO:0035690 cellular response to drug
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044281 small molecule metabolic process
GO:0050667 homocysteine metabolic process
GO:0071277 cellular response to calcium ion
GO:0071732 cellular response to nitric oxide
GO:0072340 cellular lactam catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0031225 anchored component of membrane
GO:0031528 microvillus membrane
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism of lipids and lipoproteins pathway
Arachidonic acid metabolism pathway
Aflatoxin activation and detoxification pathway
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Metabolism pathway
Biological oxidations pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.109
RefSeq NM_001128141 NM_004413 XM_005256285 XM_005256286 XM_006721159
HUGO
OMIM
CCDS CCDS10982
HPRD 01563
IMGT
EMBL
GenPept
RNA Seq Atlas