InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DPEP1

Summary

InnateDB Gene

IDBG-47798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DPEP1

Gene Name

dipeptidase 1 (renal)

Synonyms

MBD1; MDP; RDP

Species

Homo sapiens

Ensembl Gene

ENSG00000015413

Encoded Proteins

IDBP-47800

dipeptidase 1 (renal)

IDBP-244322

dipeptidase 1 (renal)

IDBP-381902

dipeptidase 1 (renal)

IDBP-749701

IDBP-751440

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a kidney membrane enzyme involved in the metabolism of glutathione and other similar proteins by dipeptide hydrolysis. The encoded protein is known to regulate leukotriene activity by catalyzing the conversion of leukotriene D4 to leukotriene E4. This protein uses zinc as a cofactor and acts as a disulfide-linked homodimer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:89613308-89638456

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000261615	ENSP00000261615
ENST00000393092	ENSP00000376807
ENST00000421184	ENSP00000397313
ENST00000570029	ENSP00000455916
ENST00000568281	ENSP00000455142
ENST00000564645
ENST00000561484
ENST00000565249
ENST00000564281

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008235	metalloexopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008239	dipeptidyl-peptidase activity
GO:0008270	zinc ion binding
GO:0016805	dipeptidase activity
GO:0034235	GPI anchor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0046872	metal ion binding
GO:0070573	metallodipeptidase activity
GO:0072341	modified amino acid binding

Biological Process

GO:0006508	proteolysis
GO:0006691	leukotriene metabolic process
GO:0006749	glutathione metabolic process
GO:0016999	antibiotic metabolic process
GO:0019369	arachidonic acid metabolic process
GO:0030336	negative regulation of cell migration
GO:0035690	cellular response to drug
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0044281	small molecule metabolic process
GO:0050667	homocysteine metabolic process
GO:0071277	cellular response to calcium ion
GO:0071732	cellular response to nitric oxide
GO:0072340	cellular lactam catabolic process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0016324	apical plasma membrane
GO:0031225	anchored component of membrane
GO:0031528	microvillus membrane
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000019278

View Gene Order

ENSBTAG00000033326

Not yet available

Pathways

NETPATH

REACTOME

REACT_150420

Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway

REACT_147851

Arachidonic acid metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_228214

Aflatoxin activation and detoxification pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

P16444

TrEMBL

H3BP43 H3BQS5

UniProt Splice Variant

Entrez Gene

1800

UniGene

Hs.109

RefSeq

NM_004413 XM_006721159 NM_001128141 XM_005256285 XM_005256286

HUGO

HGNC:3002

OMIM

179780

CCDS

CCDS10982

HPRD

01563

IMGT

EMBL

AC010538 BC017023 BT006664 CH471184 D13137 D13138 J05257 S70329 S70330

GenPept

AAB59410 AAC60630 AAH17023 AAP35310 BAA02430 BAA02431 EAW66719 EAW66720

RNA Seq Atlas

1800