Version 5.4
Mus musculus Gene: Ddah1
Summary
InnateDB Gene IDBG-198715.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ddah1
Gene Name dimethylarginine dimethylaminohydrolase 1
Synonyms 2410006N07Rik; 2510015N06Rik; AI987801; AW050362
Species Mus musculus
Ensembl Gene ENSMUSG00000028194
Encoded Proteins
IDBP-198717
dimethylarginine dimethylaminohydrolase 1
IDBP-400346
dimethylarginine dimethylaminohydrolase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153904:
This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:145758675-145894277
Strand Forward strand
Band H2
Transcripts
ENSMUST00000029845 ENSMUSP00000029845
ENSMUST00000120310 ENSMUSP00000112747
ENSMUST00000127193
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016403 dimethylargininase activity
GO:0016597 amino acid binding
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Biological Process
GO:0000052 citrulline metabolic process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006525 arginine metabolic process
GO:0006809 nitric oxide biosynthetic process
GO:0017014 protein nitrosylation
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045766 positive regulation of angiogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153904
View Gene Order
ENSBTAG00000034776
Not yet available
Cross-References
SwissProt Q9CWS0
TrEMBL D3YU15 Q3UF01
UniProt Splice Variant
Entrez Gene 69219
UniGene Mm.234247
RefSeq NM_026993 XM_006502024 XM_006502025
OMIM
CCDS CCDS17896
HPRD
IMGT
MGI ID MGI:1916469
MGI Symbol Ddah1
EMBL AC123684 AC126412 AK010430 AK143507 AK148907 AK149185 BC034505 CH466532
GenPept AAH34505 BAB26932 BAE25405 BAE28696 BAE28760 EDL11993
RNA Seq Atlas 69219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca