Version 5.4
Mus musculus Gene: Kdm2b
Summary
InnateDB Gene IDBG-198910.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kdm2b
Gene Name lysine (K)-specific demethylase 2B
Synonyms Cxxc2; E430001G17; Fbl10; Fbxl10; Jhdm1b; mKIAA3014; PCCX2
Species Mus musculus
Ensembl Gene ENSMUSG00000029475
Encoded Proteins
IDBP-198912
lysine (K)-specific demethylase 2B
IDBP-198914
lysine (K)-specific demethylase 2B
IDBP-198916
lysine (K)-specific demethylase 2B
IDBP-400268
lysine (K)-specific demethylase 2B
IDBP-400267
lysine (K)-specific demethylase 2B
IDBP-536610
lysine (K)-specific demethylase 2B
IDBP-533554
lysine (K)-specific demethylase 2B
IDBP-535825
lysine (K)-specific demethylase 2B
IDBP-536502
lysine (K)-specific demethylase 2B
IDBP-625954
lysine (K)-specific demethylase 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089094:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:122870668-123015080
Strand Reverse strand
Band F
Transcripts
ENSMUST00000046073 ENSMUSP00000038229
ENSMUST00000086200 ENSMUSP00000083376
ENSMUST00000031435 ENSMUSP00000031435
ENSMUST00000118027 ENSMUSP00000114052
ENSMUST00000121739 ENSMUSP00000114049
ENSMUST00000127403 ENSMUSP00000120912
ENSMUST00000139674
ENSMUST00000152872 ENSMUSP00000119746
ENSMUST00000132419
ENSMUST00000129998
ENSMUST00000123479
ENSMUST00000156474 ENSMUSP00000118488
ENSMUST00000145082 ENSMUSP00000114731
ENSMUST00000143273
ENSMUST00000138929
ENSMUST00000147544
ENSMUST00000134501
ENSMUST00000150543
ENSMUST00000173355
ENSMUST00000174357
ENSMUST00000172729 ENSMUSP00000133329
ENSMUST00000173670
ENSMUST00000173312
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0032452 histone demethylase activity
GO:0051864 histone demethylase activity (H3-K36 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0016577 histone demethylation
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021993 initiation of neural tube closure
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0035518 histone H2A monoubiquitination
GO:0043524 negative regulation of neuron apoptotic process
GO:0048596 embryonic camera-type eye morphogenesis
GO:0055114 oxidation-reduction process
GO:0070544 histone H3-K36 demethylation
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031519 PcG protein complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000089094
View Gene Order
ENSBTAG00000002328
Not yet available
Pathways
NETPATH
REACTOME
REACT_218274
Chromatin organization pathway
REACT_256030
HDMs demethylate histones pathway
REACT_202766
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.461188 Mm.86406
RefSeq NM_001003953 NM_001005866 NM_013910 XM_006530376 XM_006530377 XM_006530378 XM_006530379 XM_006530380 XM_006530381 XM_006530382 XM_006530383
OMIM
CCDS CCDS19657 CCDS39259 CCDS39260
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca