Version 5.4
Homo sapiens Gene: KDM2B
Summary
InnateDB Gene IDBG-61786.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM2B
Gene Name lysine (K)-specific demethylase 2B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089094
Encoded Proteins
IDBP-61788
lysine (K)-specific demethylase 2B
IDBP-61790
lysine (K)-specific demethylase 2B
IDBP-376916
lysine (K)-specific demethylase 2B
IDBP-583290
lysine (K)-specific demethylase 2B
IDBP-598207
lysine (K)-specific demethylase 2B
IDBP-810758
lysine (K)-specific demethylase 2B
IDBP-599715
lysine (K)-specific demethylase 2B
IDBP-586123
lysine (K)-specific demethylase 2B
IDBP-602257
lysine (K)-specific demethylase 2B
IDBP-593270
lysine (K)-specific demethylase 2B
IDBP-601051
lysine (K)-specific demethylase 2B
IDBP-591762
lysine (K)-specific demethylase 2B
IDBP-597635
lysine (K)-specific demethylase 2B
IDBP-597384
lysine (K)-specific demethylase 2B
IDBP-810767
lysine (K)-specific demethylase 2B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:121429097-121581015
Strand Reverse strand
Band q24.31
Transcripts
ENST00000377071 ENSP00000366271
ENST00000377069 ENSP00000366269
ENST00000446152 ENSP00000398279
ENST00000542973 ENSP00000437821
ENST00000538503
ENST00000543025 ENSP00000438138
ENST00000536036
ENST00000538243
ENST00000538046 ENSP00000474307
ENST00000542030 ENSP00000444846
ENST00000538379 ENSP00000445102
ENST00000545022 ENSP00000437497
ENST00000541318 ENSP00000443052
ENST00000543852 ENSP00000440942
ENST00000541511 ENSP00000442293
ENST00000539394 ENSP00000440373
ENST00000540191
ENST00000536437 ENSP00000445196
ENST00000611216 ENSP00000480847
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0032452 histone demethylase activity
GO:0051864 histone demethylase activity (H3-K36 specific)
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007283 spermatogenesis
GO:0016577 histone demethylation
GO:0021555 midbrain-hindbrain boundary morphogenesis
GO:0021592 fourth ventricle development
GO:0021670 lateral ventricle development
GO:0021678 third ventricle development
GO:0021993 initiation of neural tube closure
GO:0030900 forebrain development
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0035518 histone H2A monoubiquitination
GO:0043524 negative regulation of neuron apoptotic process
GO:0048596 embryonic camera-type eye morphogenesis
GO:0055114 oxidation-reduction process
GO:0070544 histone H3-K36 demethylation
GO:2000178 negative regulation of neural precursor cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0031519 PcG protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029475
View Gene Order
ENSBTAG00000002328
Not yet available
Pathways
NETPATH
REACTOME
REACT_228178
HDMs demethylate histones pathway
REACT_172623
Chromatin organization pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524800
RefSeq NM_001005366 NM_032590 XM_005253955 XM_005253956
HUGO
OMIM
CCDS CCDS41849 CCDS41850
HPRD 12362
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca