Version 5.4
Homo sapiens Gene: SYT8
Summary
InnateDB Gene IDBG-19905.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYT8
Gene Name synaptotagmin VIII
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000149043
Encoded Proteins
IDBP-19907
synaptotagmin VIII
IDBP-19909
synaptotagmin VIII
IDBP-19913
synaptotagmin VIII
IDBP-361255
synaptotagmin VIII
IDBP-361257
synaptotagmin VIII
IDBP-361271
synaptotagmin VIII
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Synaptotagmins, such as SYT8, share a common domain structure that includes a transmembrane domain and a cytoplasmic region composed of 2 C2 domains. Some synaptotagmins are involved in synaptic membrane fusion, while others have a more general function in endocytosis. For further information on synaptotagmins, see MIM 185605.[supplied by OMIM, May 2003]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:1828307-1837521
Strand Forward strand
Band p15.5
Transcripts
ENST00000381978 ENSP00000371406
ENST00000381968 ENSP00000371394
ENST00000341958 ENSP00000343691
ENST00000430303 ENSP00000392469
ENST00000417052 ENSP00000387678
ENST00000424556 ENSP00000405850
ENST00000479276
ENST00000490707
ENST00000479089
ENST00000464897
ENST00000475245
ENST00000482118
ENST00000483280
ENST00000494431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0007340 acrosome reaction
Cellular Component
GO:0001669 acrosomal vesicle
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031098
View Gene Order
ENSBTAG00000040103
Not yet available
Cross-References
SwissProt Q8NBV8
TrEMBL A6NCR4 C9J253 C9K032 F8WBL4
UniProt Splice Variant
Entrez Gene 90019
UniGene Hs.738918
RefSeq NM_001290332 NM_001290333 NM_001290334 NM_138567
HUGO HGNC:19264
OMIM 607719
CCDS CCDS7726
HPRD
IMGT
EMBL AC051649 AK075202 AL137708 AY353087
GenPept AAQ57209 BAC11467 CAB70885
RNA Seq Atlas 90019

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca