Version 5.4
Mus musculus Gene: Ece1
Summary
InnateDB Gene IDBG-199213.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ece1
Gene Name endothelin converting enzyme 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000057530
Encoded Proteins
IDBP-199215
endothelin converting enzyme 1
IDBP-531841
endothelin converting enzyme 1
IDBP-535893
endothelin converting enzyme 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117298:
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:137862237-137965229
Strand Forward strand
Band D3
Transcripts
ENSMUST00000102518 ENSMUSP00000099576
ENSMUST00000130407 ENSMUSP00000125529
ENSMUST00000151110 ENSMUSP00000114671
ENSMUST00000129607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004175 endopeptidase activity
GO:0004222 metalloendopeptidase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006508 proteolysis
GO:0007507 heart development
GO:0010814 substance P catabolic process
GO:0010815 bradykinin catabolic process
GO:0010816 calcitonin catabolic process
GO:0016485 protein processing
GO:0016486 peptide hormone processing
GO:0034959 endothelin maturation
GO:0042447 hormone catabolic process
GO:0042733 embryonic digit morphogenesis
GO:0043583 ear development
GO:0060037 pharyngeal system development
Cellular Component
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0033093 Weibel-Palade body
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000117298
View Gene Order
ENSBTAG00000002977
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.401062 Mm.483336
RefSeq NM_199307 XM_006538765 XM_006538766 XM_006538767 XM_006538768
OMIM
CCDS CCDS18822
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca