Version 5.4
Mus musculus Gene: Ino80
Summary
InnateDB Gene IDBG-199361.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ino80
Gene Name INO80 homolog (S. cerevisiae)
Synonyms 2310079N15Rik; 4632409L19Rik; Inoc1
Species Mus musculus
Ensembl Gene ENSMUSG00000034154
Encoded Proteins
IDBP-199363
INO80 homolog (S. cerevisiae)
IDBP-259456
INO80 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128908:
The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. This complex binds DNA and is recruited by YY1 to activate certain genes.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119373042-119477687
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000049920 ENSMUSP00000051845
ENSMUST00000110808 ENSMUSP00000106431
ENSMUST00000138707
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003779 actin binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016887 ATPase activity
GO:0043014 alpha-tubulin binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000724 double-strand break repair via homologous recombination
GO:0006200 ATP catabolic process
GO:0006302 double-strand break repair
GO:0006338 chromatin remodeling
GO:0008152 metabolic process
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0030307 positive regulation of cell growth
GO:0032508 DNA duplex unwinding
GO:0034644 cellular response to UV
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051225 spindle assembly
GO:0070914 UV-damage excision repair
GO:0071479 cellular response to ionizing radiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005874 microtubule
GO:0031011 Ino80 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128908
View Gene Order
ENSBTAG00000010380
Not yet available
Cross-References
SwissProt Q6ZPV2
TrEMBL Q8CE87 Q9D2N0
UniProt Splice Variant
Entrez Gene 68142
UniGene Mm.330496
RefSeq NM_026574 XM_006500092
OMIM
CCDS CCDS16602
HPRD
IMGT
MGI ID MGI:1915392
MGI Symbol Ino80
EMBL AK019483 AK028804 AK040612 AK129317 AL844862 BC059235
GenPept AAH59235 BAB31751 BAC26127 BAC30644 BAC98127 CAM22021
RNA Seq Atlas 68142

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca