Version 5.4
Homo sapiens Gene: INO80
Summary
InnateDB Gene IDBG-6884.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INO80
Gene Name INO80 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128908
Encoded Proteins
IDBP-6888
INO80 homolog (S. cerevisiae)
IDBP-292765
INO80 homolog (S. cerevisiae)
IDBP-584057
INO80 homolog (S. cerevisiae)
IDBP-594595
INO80 homolog (S. cerevisiae)
IDBP-592848
INO80 homolog (S. cerevisiae)
IDBP-812700
INO80 complex subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene represents the catalytic ATPase subunit of the INO80 chromatin remodeling complex. This complex binds DNA and is recruited by YY1 to activate certain genes.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:40978880-41116354
Strand Reverse strand
Band q15.1
Transcripts
ENST00000361937 ENSP00000355205
ENST00000401393 ENSP00000384686
ENST00000558357 ENSP00000453677
ENST00000558270
ENST00000560689
ENST00000560799
ENST00000561244
ENST00000557849 ENSP00000452806
ENST00000559995 ENSP00000454057
ENST00000561172
ENST00000616814 ENSP00000483661
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 35 [view]
Protein-Protein 33 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0003779 actin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016887 ATPase activity
GO:0043014 alpha-tubulin binding
Biological Process
GO:0000070 mitotic sister chromatid segregation
GO:0000724 double-strand break repair via homologous recombination
GO:0006200 ATP catabolic process
GO:0006302 double-strand break repair
GO:0006338 chromatin remodeling
GO:0008152 metabolic process
GO:0010571 positive regulation of nuclear cell cycle DNA replication
GO:0030307 positive regulation of cell growth
GO:0032508 DNA duplex unwinding
GO:0034644 cellular response to UV
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051225 spindle assembly
GO:0070914 UV-damage excision repair
GO:0071479 cellular response to ionizing radiation
GO:2000045 regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005874 microtubule
GO:0031011 Ino80 complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034154
View Gene Order
ENSBTAG00000010380
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.292949 Hs.606817
RefSeq NM_017553
HUGO
OMIM
CCDS CCDS10071
HPRD 10024
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca