Mus musculus Gene: Rhoa
Summary
InnateDB Gene IDBG-199633.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rhoa
Gene Name ras homolog gene family, member A
Synonyms Arha; Arha1; Arha2;
Species Mus musculus
Ensembl Gene ENSMUSG00000007815
Encoded Proteins
ras homolog gene family, member A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067560:
Gene Information
Type Protein coding
Genomic Location Chromosome 9:108306205-108337939
Strand Forward strand
Band F1
Transcripts
ENSMUST00000007959 ENSMUSP00000007959
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 41 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 100 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001666 response to hypoxia
GO:0006184 GTP catabolic process
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007010 cytoskeleton organization
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007229 integrin-mediated signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007266 Rho protein signal transduction
GO:0007519 skeletal muscle tissue development
GO:0008064 regulation of actin polymerization or depolymerization
GO:0009612 response to mechanical stimulus
GO:0009749 response to glucose
GO:0015031 protein transport
GO:0021795 cerebral cortex cell migration
GO:0021861 forebrain radial glial cell differentiation
GO:0030036 actin cytoskeleton organization
GO:0030154 cell differentiation
GO:0030307 positive regulation of cell growth
GO:0030334 regulation of cell migration
GO:0030335 positive regulation of cell migration
GO:0030521 androgen receptor signaling pathway
GO:0030838 positive regulation of actin filament polymerization
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032467 positive regulation of cytokinesis
GO:0033144 negative regulation of intracellular steroid hormone receptor signaling pathway
GO:0033688 regulation of osteoblast proliferation
GO:0036089 cleavage furrow formation
GO:0042493 response to drug
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043149 stress fiber assembly
GO:0043200 response to amino acid
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043297 apical junction assembly
GO:0043524 negative regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0043931 ossification involved in bone maturation
GO:0045471 response to ethanol
GO:0045665 negative regulation of neuron differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045727 positive regulation of translation
GO:0045785 positive regulation of cell adhesion
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0048812 neuron projection morphogenesis
GO:0050773 regulation of dendrite development
GO:0051384 response to glucocorticoid
GO:0051496 positive regulation of stress fiber assembly
GO:0051924 regulation of calcium ion transport
GO:0060548 negative regulation of cell death
GO:0061383 trabecula morphogenesis
GO:0071803 positive regulation of podosome assembly
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0030424 axon
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
GPCR downstream signaling pathway
PI3K/AKT activation pathway
p75NTR regulates axonogenesis pathway
Disease pathway
Hemostasis pathway
Signaling by Wnt pathway
Signaling by GPCR pathway
Signaling by VEGF pathway
Loss of Function of SMAD4 in Cancer pathway
beta-catenin independent WNT signaling pathway
EPHA-mediated growth cone collapse pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Axonal growth inhibition (RHOA activation) pathway
TGFBR1 LBD Mutants in Cancer pathway
Platelet activation, signaling and aggregation pathway
Loss of Function of TGFBR2 in Cancer pathway
Signaling by Rho GTPases pathway
PCP/CE pathway pathway
Sema4D induced cell migration and growth-cone collapse pathway
GPVI-mediated activation cascade pathway
EPH-Ephrin signaling pathway
G alpha (12/13) signalling events pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
EPHB-mediated forward signaling pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
VEGFA-VEGFR2 Pathway pathway
Axon guidance pathway
Rho GTPase cycle pathway
Axonal growth stimulation pathway
Sema4D in semaphorin signaling pathway
Signalling by NGF pathway
Developmental Biology pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Semaphorin interactions pathway
NGF signalling via TRKA from the plasma membrane pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Sema4D mediated inhibition of cell attachment and migration pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
TGFBR1 KD Mutants in Cancer pathway
p75 NTR receptor-mediated signalling pathway
G beta:gamma signalling through PI3Kgamma pathway
Signaling by TGF-beta Receptor Complex pathway
Loss of Function of SMAD2/3 in Cancer pathway
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
T cell receptor signaling pathway pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pancreatic secretion pathway
Bacterial invasion of epithelial cells pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Alpha6Beta4Integrin pathway
EGFR1 pathway
TGF_beta_Receptor pathway
Wnt pathway
TSH pathway
REACTOME
PCP/CE pathway pathway
Sema4D in semaphorin signaling pathway
G alpha (12/13) signalling events pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
Developmental Biology pathway
Signalling by NGF pathway
PI3K/AKT activation pathway
p75NTR regulates axonogenesis pathway
Sema4D mediated inhibition of cell attachment and migration pathway
Loss of Function of SMAD4 in Cancer pathway
Loss of Function of SMAD2/3 in Cancer pathway
beta-catenin independent WNT signaling pathway
Semaphorin interactions pathway
EPHB-mediated forward signaling pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
Signaling by Wnt pathway
Signaling by Rho GTPases pathway
Signaling by VEGF pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Axon guidance pathway
Axonal growth stimulation pathway
p75 NTR receptor-mediated signalling pathway
Axonal growth inhibition (RHOA activation) pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
Signal Transduction pathway
GPCR downstream signaling pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Loss of Function of TGFBR2 in Cancer pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
EPHA-mediated growth cone collapse pathway
GPVI-mediated activation cascade pathway
Rho GTPase cycle pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
TGFBR1 KD Mutants in Cancer pathway
EPH-Ephrin signaling pathway
Loss of Function of TGFBR1 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
G beta:gamma signalling through PI3Kgamma pathway
Sema4D induced cell migration and growth-cone collapse pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Disease pathway
Hemostasis pathway
Signaling by TGF-beta Receptor Complex pathway
Signaling by Wnt pathway
EPHA-mediated growth cone collapse pathway
Sema4D in semaphorin signaling pathway
Loss of Function of TGFBR1 in Cancer pathway
Signaling by TGF-beta Receptor Complex pathway
SMAD2/3 MH2 Domain Mutants in Cancer pathway
Signaling by GPCR pathway
p75NTR regulates axonogenesis pathway
Loss of Function of SMAD4 in Cancer pathway
Sema4D induced cell migration and growth-cone collapse pathway
Loss of Function of TGFBR2 in Cancer pathway
Sema4D mediated inhibition of cell attachment and migration pathway
VEGFA-VEGFR2 Pathway pathway
Hemostasis pathway
Platelet activation, signaling and aggregation pathway
Axonal growth inhibition (RHOA activation) pathway
Rho GTPase cycle pathway
EPH-Ephrin signaling pathway
TGFBR2 Kinase Domain Mutants in Cancer pathway
Signal Transduction pathway
GPVI-mediated activation cascade pathway
Signaling by Rho GTPases pathway
Axon guidance pathway
Signaling by TGF-beta Receptor Complex in Cancer pathway
beta-catenin independent WNT signaling pathway
NGF signalling via TRKA from the plasma membrane pathway
PCP/CE pathway pathway
GPCR downstream signaling pathway
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
Signalling by NGF pathway
Signaling by VEGF pathway
G alpha (12/13) signalling events pathway
G-protein beta:gamma signalling pathway
SMAD4 MH2 Domain Mutants in Cancer pathway
TGFBR2 MSI Frameshift Mutants in Cancer pathway
p75 NTR receptor-mediated signalling pathway
EPHB-mediated forward signaling pathway
PI3K/AKT activation pathway
Axonal growth stimulation pathway
Loss of Function of SMAD2/3 in Cancer pathway
TGFBR1 LBD Mutants in Cancer pathway
Disease pathway
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
TGFBR1 KD Mutants in Cancer pathway
G beta:gamma signalling through PI3Kgamma pathway
Semaphorin interactions pathway
Developmental Biology pathway
KEGG
Chemokine signaling pathway pathway
Endocytosis pathway
Vascular smooth muscle contraction pathway
Wnt signaling pathway pathway
TGF-beta signaling pathway pathway
Axon guidance pathway
Focal adhesion pathway
Adherens junction pathway
Tight junction pathway
T cell receptor signaling pathway pathway
Leukocyte transendothelial migration pathway
Neurotrophin signaling pathway pathway
Regulation of actin cytoskeleton pathway
Pancreatic secretion pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Pathways in cancer pathway
Colorectal cancer pathway
INOH
Integrin signaling pathway pathway
PID BIOCARTA
Ucalpain and friends in cell spread [Biocarta view]
Ccr3 signaling in eosinophils [Biocarta view]
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Integrin signaling pathway [Biocarta view]
Thrombin signaling and protease-activated receptors [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Trefoil factors initiate mucosal healing [Biocarta view]
Ras signaling pathway [Biocarta view]
Rho-selective guanine exchange factor akap13 mediates stress fiber formation [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
Role of mal in rho-mediated activation of srf [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
D4gdi signaling pathway [Biocarta view]
Protein kinase a at the centrosome [Biocarta view]
Influence of ras and rho proteins on g1 to s transition [Biocarta view]
PID NCI
Syndecan-2-mediated signaling events
EPHA forward signaling
Thromboxane A2 receptor signaling
E-cadherin signaling in the nascent adherens junction
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Class I PI3K signaling events
S1P1 pathway
LPA receptor mediated events
IL2-mediated signaling events
Netrin-mediated signaling events
Integrins in angiogenesis
S1P2 pathway
Signaling events mediated by PTP1B
PAR1-mediated thrombin signaling events
Signaling events mediated by focal adhesion kinase
Regulation of RhoA activity
p75(NTR)-mediated signaling
Signaling events mediated by PRL
S1P5 pathway
S1P3 pathway
S1P4 pathway
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-4-mediated signaling events
Plasma membrane estrogen receptor signaling
PAR4-mediated thrombin signaling events
Signaling events regulated by Ret tyrosine kinase
SHP2 signaling
Arf6 downstream pathway
RhoA signaling pathway
Noncanonical Wnt signaling pathway
EPHA2 forward signaling
Aurora B signaling
a4b7 Integrin signaling
Stabilization and expansion of the E-cadherin adherens junction
Lissencephaly gene (LIS1) in neuronal migration and development
E-cadherin signaling in keratinocytes
PDGFR-beta signaling pathway
amb2 Integrin signaling
Endogenous TLR signaling
N-cadherin signaling events
PLK1 signaling events
Cross-References
SwissProt Q9QUI0
TrEMBL Q4VAE6
UniProt Splice Variant
Entrez Gene 11848
UniGene Mm.471953
RefSeq NM_016802 XM_006511633
OMIM
CCDS CCDS23521
HPRD
IMGT
MGI ID MGI:1096342
MGI Symbol Rhoa
EMBL AF014371 AF178958 AF178959 AF178960 AF178961 AK077606 AK083624 AK150475 AK152629 AK172051 BC068115 BC096423 CH466560 JN971019
GenPept AAC23710 AAD52675 AAD52676 AAD52677 AAD52678 AAH68115 AAH96423 AFR23588 BAC36896 BAC38971 BAE29592 BAE31372 BAE42800 EDL21278 EDL21279
RNA Seq Atlas 11848