Mus musculus Gene: Itpka
Summary
InnateDB Gene IDBG-199875.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Itpka
Gene Name inositol 1,4,5-trisphosphate 3-kinase A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000027296
Encoded Proteins
inositol 1,4,5-trisphosphate 3-kinase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137825:
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:119742337-119751263
Strand Forward strand
Band E5
Transcripts
ENSMUST00000028758 ENSMUSP00000028758
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0006020 inositol metabolic process
GO:0006468 protein phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0048167 regulation of synaptic plasticity
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0097062 dendritic spine maintenance
Cellular Component
GO:0043197 dendritic spine
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Inositol phosphate metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
Inositol phosphate metabolism pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Inositol phosphate metabolism pathway
Metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
Inositol phosphate metabolism pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.407958 Mm.65337
RefSeq NM_146125
OMIM
CCDS CCDS16607
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas