InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itpka

Summary

InnateDB Gene

IDBG-199875.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itpka

Gene Name

inositol 1,4,5-trisphosphate 3-kinase A

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027296

Encoded Proteins

IDBP-199877

inositol 1,4,5-trisphosphate 3-kinase A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137825:
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:119742337-119751263

Strand

Forward strand

Band

Transcripts

ENSMUST00000028758

ENSMUSP00000028758

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004683	calmodulin-dependent protein kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0006020	inositol metabolic process
GO:0006468	protein phosphorylation
GO:0030036	actin cytoskeleton organization
GO:0048167	regulation of synaptic plasticity
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0097062	dendritic spine maintenance

Cellular Component

GO:0043197

dendritic spine

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000137825

View Gene Order

ENSBTAG00000001675

Not yet available

Pathways

NETPATH

REACTOME

REACT_188937

Metabolism pathway

REACT_196476

Inositol phosphate metabolism pathway

REACT_196473

Synthesis of IP3 and IP4 in the cytosol pathway

KEGG

mmu04020

Calcium signaling pathway pathway

mmu04070

Phosphatidylinositol signaling system pathway

mmu00562

Inositol phosphate metabolism pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_150312

Synthesis of IP3 and IP4 in the cytosol pathway

REACT_150154

Inositol phosphate metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00562

Inositol phosphate metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa04020

Calcium signaling pathway pathway

INOH

INOH website

Inositol phosphate metabolism pathway

PID NCI

Cross-References

SwissProt

Q8R071

TrEMBL

UniProt Splice Variant

Entrez Gene

228550

UniGene

Mm.407958 Mm.65337

RefSeq

NM_146125

OMIM

CCDS

CCDS16607

HPRD

IMGT

MGI ID

MGI:1333822

MGI Symbol

Itpka

EMBL

AL844536 BC027291

GenPept

AAH27291 CAM18079

RNA Seq Atlas

228550