Homo sapiens Gene: ITPKA
Summary
InnateDB Gene IDBG-7097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPKA
Gene Name inositol-trisphosphate 3-kinase A
Synonyms IP3-3KA; IP3KA;
Species Homo sapiens
Ensembl Gene ENSG00000137825
Encoded Proteins
inositol-trisphosphate 3-kinase A
inositol-trisphosphate 3-kinase A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:41493393-41503551
Strand Forward strand
Band q15.1
Transcripts
ENST00000260386 ENSP00000260386
ENST00000425927 ENSP00000396560
ENST00000462816
ENST00000491007
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004683 calmodulin-dependent protein kinase activity
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0006020 inositol metabolic process
GO:0006468 protein phosphorylation
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0030036 actin cytoskeleton organization
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0048167 regulation of synaptic plasticity
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0097062 dendritic spine maintenance
Cellular Component
GO:0005829 cytosol
GO:0043197 dendritic spine
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Inositol phosphate metabolism pathway
Metabolism pathway
Synthesis of IP3 and IP4 in the cytosol pathway
KEGG
Inositol phosphate metabolism pathway
Calcium signaling pathway pathway
Phosphatidylinositol signaling system pathway
INOH
Inositol phosphate metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt P23677
TrEMBL C9JC74
UniProt Splice Variant
Entrez Gene 3706
UniGene Hs.2722
RefSeq NM_002220 XM_005254348
HUGO HGNC:6178
OMIM 147521
CCDS CCDS10076
HPRD
IMGT
EMBL AC087721 BC026331 X54938
GenPept AAH26331 CAA38700
RNA Seq Atlas 3706