InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITPKA

Summary

InnateDB Gene

IDBG-7097.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPKA

Gene Name

inositol-trisphosphate 3-kinase A

Synonyms

IP3-3KA; IP3KA

Species

Homo sapiens

Ensembl Gene

ENSG00000137825

Encoded Proteins

IDBP-7099

inositol-trisphosphate 3-kinase A

IDBP-367060

inositol-trisphosphate 3-kinase A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:41493393-41503551

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000260386	ENSP00000260386
ENST00000425927	ENSP00000396560
ENST00000462816
ENST00000491007

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004683	calmodulin-dependent protein kinase activity
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity
GO:0048365	Rac GTPase binding

Biological Process

GO:0006020	inositol metabolic process
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0016310	phosphorylation
GO:0030036	actin cytoskeleton organization
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0048167	regulation of synaptic plasticity
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0097062	dendritic spine maintenance

Cellular Component

GO:0005829	cytosol
GO:0043197	dendritic spine

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027296

View Gene Order

ENSBTAG00000001675

Not yet available

Pathways

NETPATH

REACTOME

REACT_150312

Synthesis of IP3 and IP4 in the cytosol pathway

REACT_150154

Inositol phosphate metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00562

Inositol phosphate metabolism pathway

hsa04070

Phosphatidylinositol signaling system pathway

hsa04020

Calcium signaling pathway pathway

INOH

INOH website

Inositol phosphate metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

C9JC74

UniProt Splice Variant

Entrez Gene

3706

UniGene

Hs.2722

RefSeq

NM_002220 XM_005254348

HUGO

HGNC:6178

OMIM

147521

CCDS

CCDS10076

HPRD

00941

IMGT

EMBL

AC087721

GenPept

RNA Seq Atlas

3706