InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo7a

Summary

InnateDB Gene

IDBG-200041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo7a

Gene Name

myosin VIIA

Synonyms

Hdb; Myo7; nmf371; polka; sh-1; sh1; USH1B

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030761

Encoded Proteins

IDBP-200043

myosin VIIA

IDBP-267291

myosin VIIA

IDBP-267293

myosin VIIA

IDBP-267299

myosin VIIA

IDBP-535469

myosin VIIA

IDBP-541000

myosin VIIA

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000137474:
This gene is a member of the myosin gene family. Myosins are mechanochemical proteins characterized by the presence of a motor domain, an actin-binding domain, a neck domain that interacts with other proteins, and a tail domain that serves as an anchor. This gene encodes an unconventional myosin with a very short tail. Defects in this gene are associated with the mouse shaker-1 phenotype and the human Usher syndrome 1B which are characterized by deafness, reduced vestibular function, and (in human) retinal degeneration. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:98051060-98119524

Strand

Reverse strand

Band

Transcripts

ENSMUST00000084979	ENSMUSP00000082046
ENSMUST00000107128	ENSMUSP00000102745
ENSMUST00000107127	ENSMUSP00000102744
ENSMUST00000107122	ENSMUSP00000102739
ENSMUST00000156992
ENSMUST00000124787
ENSMUST00000152975
ENSMUST00000153657	ENSMUSP00000114723
ENSMUST00000155637
ENSMUST00000149079
ENSMUST00000138627	ENSMUSP00000114944
ENSMUST00000131632

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0019904	protein domain specific binding
GO:0030507	spectrin binding
GO:0030898	actin-dependent ATPase activity
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0043531	ADP binding
GO:0051015	actin filament binding

Biological Process

GO:0001845	phagolysosome assembly
GO:0006200	ATP catabolic process
GO:0006886	intracellular protein transport
GO:0006909	phagocytosis
GO:0007040	lysosome organization
GO:0007600	sensory perception
GO:0007601	visual perception
GO:0007605	sensory perception of sound
GO:0008152	metabolic process
GO:0030030	cell projection organization
GO:0030048	actin filament-based movement
GO:0042472	inner ear morphogenesis
GO:0042490	mechanoreceptor differentiation
GO:0042491	auditory receptor cell differentiation
GO:0048563	post-embryonic organ morphogenesis
GO:0048839	inner ear development
GO:0050953	sensory perception of light stimulus
GO:0050957	equilibrioception
GO:0051875	pigment granule localization
GO:0051904	pigment granule transport
GO:0060088	auditory receptor cell stereocilium organization
GO:0060113	inner ear receptor cell differentiation

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0001917	photoreceptor inner segment
GO:0005737	cytoplasm
GO:0005765	lysosomal membrane
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005902	microvillus
GO:0005938	cell cortex
GO:0016324	apical plasma membrane
GO:0016459	myosin complex
GO:0031477	myosin VII complex
GO:0032391	photoreceptor connecting cilium
GO:0032420	stereocilium
GO:0042470	melanosome
GO:0045202	synapse