InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Impdh2

Summary

InnateDB Gene

IDBG-200174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Impdh2

Gene Name

inosine 5'-phosphate dehydrogenase 2

Synonyms

IMPD

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062867

Encoded Proteins

IDBP-200176

inosine 5'-phosphate dehydrogenase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21460227

Impdh2 proteins are rapidly recruited to the lipid raft of monocytes after lipopeptide stimulation, and play an essential role in the negative regulation of Tlr2 signalling by modulating PI3K activity. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 21460227

[Homo sapiens] IMPDH2 proteins are rapidly recruited to the lipid raft of monocytes after lipopeptide stimulation, and play an essential role in the negative regulation of TLR2 signalling by modulating PI3K activity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178035:
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5\'-monophosphate into xanthine-5\'-monophosphate, which is then converted into guanosine-5\'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:108560534-108565519

Strand

Forward strand

Band

Transcripts

ENSMUST00000081111

ENSMUSP00000079888

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003824	catalytic activity
GO:0003938	IMP dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0018580	nitronate monooxygenase activity
GO:0030554	adenyl nucleotide binding
GO:0046872	metal ion binding
GO:0047465	N-acylglucosamine-6-phosphate 2-epimerase activity

Biological Process

GO:0006051	N-acetylmannosamine metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006177	GMP biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046651	lymphocyte proliferation
GO:0051289	protein homotetramerization
GO:0055114	oxidation-reduction process
GO:0060041	retina development in camera-type eye
GO:0071353	cellular response to interleukin-4