Version 5.4
Homo sapiens Gene: IMPDH2
Summary
InnateDB Gene IDBG-34157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IMPDH2
Gene Name IMP (inosine 5'-monophosphate) dehydrogenase 2
Synonyms IMPD2; IMPDH-II
Species Homo sapiens
Ensembl Gene ENSG00000178035
Encoded Proteins
IDBP-34159
IMP (inosine 5'-monophosphate) dehydrogenase 2
IDBP-376768
IMP (inosine 5'-monophosphate) dehydrogenase 2
IDBP-376771
IMP (inosine 5'-monophosphate) dehydrogenase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21460227
IMPDH2 proteins are rapidly recruited to the lipid raft of monocytes after lipopeptide stimulation, and play an essential role in the negative regulation of TLR2 signalling by modulating PI3K activity.
InnateDB Annotation from Orthologs
Summary
PMID 21460227
[Mus musculus] Impdh2 proteins are rapidly recruited to the lipid raft of monocytes after lipopeptide stimulation, and play an essential role in the negative regulation of Tlr2 signalling by modulating PI3K activity. (Demonstrated in human)
Entrez Gene
Summary This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5\'-monophosphate into xanthine-5\'-monophosphate, which is then converted into guanosine-5\'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:49024325-49029408
Strand Reverse strand
Band p21.31
Transcripts
ENST00000326739 ENSP00000321584
ENST00000429182 ENSP00000393525
ENST00000442157 ENSP00000403502
ENST00000472328
ENST00000466147
ENST00000463903
ENST00000484872
ENST00000481274
ENST00000462980
ENST00000491610
ENST00000485500
ENST00000496837
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 40 [view]
Protein-Protein 39 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0018580 nitronate monooxygenase activity
GO:0030554 adenyl nucleotide binding
GO:0046872 metal ion binding
GO:0047465 N-acylglucosamine-6-phosphate 2-epimerase activity
Biological Process
GO:0006051 N-acetylmannosamine metabolic process
GO:0006144 purine nucleobase metabolic process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0009168 purine ribonucleoside monophosphate biosynthetic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response (InnateDB)
GO:0046651 lymphocyte proliferation
GO:0051289 protein homotetramerization
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
GO:0060041 retina development in camera-type eye
GO:0071353 cellular response to interleukin-4
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062867
View Gene Order
ENSBTAG00000031837
Not yet available
Pathways
NETPATH
REACTOME
REACT_1776
Purine ribonucleoside monophosphate biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_522
Purine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_000884 XM_006713128
HUGO
OMIM
CCDS CCDS2786
HPRD 00895
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca