Version 5.4
Mus musculus Gene: Capzb
Summary
InnateDB Gene IDBG-200253.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Capzb
Gene Name capping protein (actin filament) muscle Z-line, beta
Synonyms 1700120C01Rik; AI325129; Cappb1; CPB1; CPB2; CPbeat2; CPbeta1; CPbeta2
Species Mus musculus
Ensembl Gene ENSMUSG00000028745
Encoded Proteins
IDBP-200255
capping protein (actin filament) muscle Z-line, beta
IDBP-200257
capping protein (actin filament) muscle Z-line, beta
IDBP-200261
capping protein (actin filament) muscle Z-line, beta
IDBP-200263
capping protein (actin filament) muscle Z-line, beta
IDBP-534331
capping protein (actin filament) muscle Z-line, beta
IDBP-539203
capping protein (actin filament) muscle Z-line, beta
IDBP-533958
capping protein (actin filament) muscle Z-line, beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077549:
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Apr 2011]
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:139192899-139291818
Strand Forward strand
Band D3
Transcripts
ENSMUST00000102508 ENSMUSP00000099566
ENSMUST00000102507 ENSMUSP00000099565
ENSMUST00000030518 ENSMUSP00000030518
ENSMUST00000042675 ENSMUSP00000038011
ENSMUST00000131912 ENSMUSP00000114973
ENSMUST00000131793
ENSMUST00000150077
ENSMUST00000156760
ENSMUST00000145368 ENSMUSP00000119252
ENSMUST00000138045 ENSMUSP00000122077
ENSMUST00000132385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0048487 beta-tubulin binding
GO:0051015 actin filament binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0022604 regulation of cell morphogenesis
GO:0030030 cell projection organization
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0031115 negative regulation of microtubule polymerization
GO:0031175 neuron projection development
GO:0048747 muscle fiber development
GO:0051016 barbed-end actin filament capping
GO:0090036 regulation of protein kinase C signaling
Cellular Component
GO:0001669 acrosomal vesicle
GO:0008290 F-actin capping protein complex
GO:0014704 intercalated disc
GO:0016020 membrane
GO:0030018 Z disc
GO:0030027 lamellipodium
GO:0030863 cortical cytoskeleton
GO:0033150 cytoskeletal calyx
GO:0071203 WASH complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000077549
View Gene Order
ENSBTAG00000004554
Not yet available
Pathways
NETPATH
REACTOME
REACT_224553
Hemostasis pathway
REACT_198649
Factors involved in megakaryocyte development and platelet production pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
REACT_215067
Factors involved in megakaryocyte development and platelet production pathway
REACT_212196
Hemostasis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.408887
RefSeq NM_001037761 NM_001271405 NM_001271406 NM_009798 XM_006538504 XM_006538505
OMIM
CCDS CCDS18841 CCDS18842 CCDS71503 CCDS71504
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca