Homo sapiens Gene: CAPZB | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-92609.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | CAPZB | ||||||||||||||||||||||||
Gene Name | capping protein (actin filament) muscle Z-line, beta | ||||||||||||||||||||||||
Synonyms | CAPB; CAPPB; CAPZ | ||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||
Ensembl Gene | ENSG00000077549 | ||||||||||||||||||||||||
Encoded Proteins |
capping protein (actin filament) muscle Z-line, beta
capping protein (actin filament) muscle Z-line, beta
capping protein (actin filament) muscle Z-line, beta
capping protein (actin filament) muscle Z-line, beta
capping protein (actin filament) muscle Z-line, beta
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Protein Structure | |||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Apr 2011] This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 1:19338776-19485539 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | p36.13 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
Factors involved in megakaryocyte development and platelet production pathway
Hemostasis pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||
SwissProt | P47756 | ||||||||||||||||||||||||
TrEMBL | B1AK85 B1AK87 B1AK88 F6USW4 Q7L4N0 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 832 | ||||||||||||||||||||||||
UniGene | Hs.432760 | ||||||||||||||||||||||||
RefSeq | NM_001206540 NM_001206541 NM_001282162 NM_004930 XM_006710938 | ||||||||||||||||||||||||
HUGO | HGNC:1491 | ||||||||||||||||||||||||
OMIM | 601572 | ||||||||||||||||||||||||
CCDS | CCDS41277 CCDS55579 CCDS72717 CCDS72718 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
EMBL | AK125085 AL035413 AL359199 AL445163 BC008095 BC024601 BC107752 BC109241 BC109242 BT019470 BT019471 CH471134 U03271 | ||||||||||||||||||||||||
GenPept | AAA87395 AAH08095 AAH24601 AAI07753 AAI09242 AAI09243 AAV38277 AAV38278 BAG54137 CAH71392 CAH72124 CAI22231 EAW94888 EAW94890 EAW94891 | ||||||||||||||||||||||||
RNA Seq Atlas | 832 | ||||||||||||||||||||||||