Version 5.4
Homo sapiens Gene: LSM3
Summary
InnateDB Gene IDBG-20051.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LSM3
Gene Name LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170860
Encoded Proteins
IDBP-20053
LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:14178358-14201119
Strand Forward strand
Band p25.1
Transcripts
ENST00000306024 ENSP00000302160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 53 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000398 mRNA splicing, via spliceosome
GO:0006397 mRNA processing
GO:0010467 gene expression
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034192
View Gene Order
ENSBTAG00000007363
Not yet available
Pathways
NETPATH
REACTOME
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
hsa03040
Spliceosome pathway
INOH
PID NCI
Cross-References
SwissProt P62310
TrEMBL
UniProt Splice Variant
Entrez Gene 27258
UniGene Hs.587203 Hs.588160 Hs.614272
RefSeq NM_014463
HUGO HGNC:17874
OMIM 607283
CCDS CCDS2619
HPRD
IMGT
EMBL AF182289 AF182418 AJ238095 BC007055 CH471055 CR457185
GenPept AAD56227 AAG14954 AAH07055 CAB45866 CAG33466 EAW64190
RNA Seq Atlas 27258

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca