InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aldh4a1

Summary

InnateDB Gene

IDBG-200918.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aldh4a1

Gene Name

aldehyde dehydrogenase 4 family, member A1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028737

Encoded Proteins

IDBP-200922

aldehyde dehydrogenase 4 family, member A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159423:
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:139622866-139649690

Strand

Forward strand

Band

Transcripts

ENSMUST00000039818	ENSMUSP00000043821
ENSMUST00000146309
ENSMUST00000124987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0006561	proline biosynthetic process
GO:0008152	metabolic process
GO:0010133	proline catabolic process to glutamate
GO:0055114	oxidation-reduction process