InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ALDH4A1

Summary

InnateDB Gene

IDBG-645770.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDH4A1

Gene Name

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000030335

Encoded Proteins

IDBP-698517

Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159423:
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrix NAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, converting pyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, an autosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:134345970-134380241

Strand

Forward strand

Band

Transcripts

ENSBTAT00000020285

ENSBTAP00000020285

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003842	1-pyrroline-5-carboxylate dehydrogenase activity
GO:0016491	oxidoreductase activity
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802	identical protein binding

Biological Process

GO:0006537	glutamate biosynthetic process
GO:0006560	proline metabolic process
GO:0006561	proline biosynthetic process
GO:0008152	metabolic process
GO:0010133	proline catabolic process to glutamate
GO:0055114	oxidation-reduction process