Version 5.4
Mus musculus Gene: Six2
Summary
InnateDB Gene IDBG-201038.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Six2
Gene Name sine oculis-related homeobox 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000024134
Encoded Proteins
IDBP-201040
sine oculis-related homeobox 2 homolog (Drosophila)
IDBP-622112
sine oculis-related homeobox 2 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170577:
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]
This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila \'sine oculis\' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:85684277-85688274
Strand Reverse strand
Band E4
Transcripts
ENSMUST00000024947 ENSMUSP00000024947
ENSMUST00000163568 ENSMUSP00000125871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0032403 protein complex binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001656 metanephros development
GO:0001822 kidney development
GO:0002062 chondrocyte differentiation
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006355 regulation of transcription, DNA-templated
GO:0006606 protein import into nucleus
GO:0007501 mesodermal cell fate specification
GO:0008283 cell proliferation
GO:0042474 middle ear morphogenesis
GO:0045596 negative regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0048704 embryonic skeletal system morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170577
View Gene Order
ENSBTAG00000004159
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_011380 XM_006523931
OMIM
CCDS CCDS29007
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca