InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Six2

Summary

InnateDB Protein

IDBP-201040.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Six2

Protein Name

sine oculis-related homeobox 2 homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024947

InnateDB Gene

IDBG-201038 (Six2)

Protein Structure

UniProt Annotation

Function

May be involved in limb tendon and ligament development.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in phalangeal tendons, in smooth muscle and in head and body mesenchyme.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001656	metanephros development
GO:0002062	chondrocyte differentiation
GO:0003337	mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0006606	protein import into nucleus
GO:0007501	mesodermal cell fate specification
GO:0008283	cell proliferation
GO:0042474	middle ear morphogenesis
GO:0045596	negative regulation of cell differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048701	embryonic cranial skeleton morphogenesis
GO:0048704	embryonic skeletal system morphogenesis

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:102778

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like

PFAM

PF00046

PRINTS

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q62232

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

20472

UniGene

RefSeq

MGI ID

MGI Symbol

Six2

OMIM

CCDS

CCDS29007

HPRD

IMGT

EMBL

BC068021 D83147 X80338

GenPept

AAH68021 BAA11825 CAA56584