Homo sapiens Gene: FLT1
Summary
InnateDB Gene IDBG-20108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FLT1
Gene Name fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Synonyms FLT; FLT-1; VEGFR-1; VEGFR1;
Species Homo sapiens
Ensembl Gene ENSG00000102755
Encoded Proteins
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
fms-related tyrosine kinase 1
fms-related tyrosine kinase 1
fms-related tyrosine kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:28300344-28495128
Strand Reverse strand
Band q12.3
Transcripts
ENST00000282397 ENSP00000282397
ENST00000540678 ENSP00000443311
ENST00000543394 ENSP00000437841
ENST00000541932 ENSP00000437631
ENST00000539099 ENSP00000442630
ENST00000615840 ENSP00000484039
ENST00000617835 ENSP00000484832
ENST00000615611 ENSP00000484385
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005021 vascular endothelial growth factor-activated receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019838 growth factor binding
GO:0036326 VEGF-A-activated receptor activity
GO:0036327 VEGF-B-activated receptor activity
GO:0036332 placental growth factor-activated receptor activity
GO:0042802 identical protein binding
Biological Process
GO:0001525 angiogenesis
GO:0001569 patterning of blood vessels
GO:0002040 sprouting angiogenesis
GO:0002548 monocyte chemotaxis
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284 positive regulation of cell proliferation
GO:0010863 positive regulation of phospholipase C activity
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036323 vascular endothelial growth factor receptor-1 signaling pathway
GO:0043406 positive regulation of MAP kinase activity
GO:0043410 positive regulation of MAPK cascade
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0045766 positive regulation of angiogenesis
GO:0046777 protein autophosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0048598 embryonic morphogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
VEGF ligand-receptor interactions pathway
Signaling by VEGF pathway
Signal Transduction pathway
VEGF binds to VEGFR leading to receptor dimerization pathway
Neurophilin interactions with VEGF and VEGFR pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Endocytosis pathway
Focal adhesion pathway
INOH
IL-7 signaling pathway
JAK STAT pathway and regulation pathway
EPO signaling pathway pathway
VEGF signaling pathway pathway
PID BIOCARTA
Vegf hypoxia and angiogenesis [Biocarta view]
Actions of nitric oxide in the heart [Biocarta view]
PID NCI
VEGF and VEGFR signaling network
Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
Signaling events mediated by VEGFR1 and VEGFR2
VEGFR1 specific signals
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 2321
UniGene
RefSeq NM_001159920 NM_002019 NM_001160030 NM_001160031
HUGO HGNC:3763
OMIM 165070
CCDS CCDS73556 CCDS9330 CCDS53860 CCDS53861
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 2321