Version 5.4
Mus musculus Gene: Ppme1
Summary
InnateDB Gene IDBG-201216.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppme1
Gene Name protein phosphatase methylesterase 1
Synonyms 1110069N17Rik; 2700017M01Rik; PME-1; Pme1
Species Mus musculus
Ensembl Gene ENSMUSG00000030718
Encoded Proteins
IDBP-201218
protein phosphatase methylesterase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000214517:
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:100326737-100371896
Strand Reverse strand
Band E2
Transcripts
ENSMUST00000032963 ENSMUSP00000032963
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0019903 protein phosphatase binding
GO:0051721 protein phosphatase 2A binding
GO:0051722 protein C-terminal methylesterase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0006482 protein demethylation
Cellular Component
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000214517
View Gene Order
ENSBTAG00000027612
Not yet available
Cross-References
SwissProt Q8BVQ5
TrEMBL
UniProt Splice Variant
Entrez Gene 72590
UniGene Mm.177502 Mm.490280
RefSeq NM_028292
OMIM
CCDS CCDS40036
HPRD
IMGT
MGI ID MGI:1919840
MGI Symbol Ppme1
EMBL AK012256 AK146051 AK146268 AK154876 BC014867 BC029064
GenPept AAH14867 AAH29064 BAB28122 BAE26861 BAE27027 BAE32896
RNA Seq Atlas 72590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca