InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppme1

Summary

InnateDB Protein

IDBP-201218.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppme1

Protein Name

protein phosphatase methylesterase 1

Synonyms

1110069N17Rik; 2700017M01Rik; PME-1; Pme1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032963

InnateDB Gene

IDBG-201216 (Ppme1)

Protein Structure

UniProt Annotation

Function

Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in testis and brain. {ECO:0000269PubMed:10318862}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0019903	protein phosphatase binding
GO:0051721	protein phosphatase 2A binding
GO:0051722	protein C-terminal methylesterase activity
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0006482

protein demethylation

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1919840

InterPro

IPR000073 Alpha/beta hydrolase fold-1
IPR000639 Epoxide hydrolase-like
IPR016812 Protein phosphatase methylesterase, eukaryotic
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF00561

PRINTS

PR00111
PR00412

PIRSF

PIRSF022950

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt