Mus musculus Gene: Padi4
Summary
InnateDB Gene IDBG-201304.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Padi4
Gene Name peptidyl arginine deiminase, type IV
Synonyms Pad4; Pdi4;
Species Mus musculus
Ensembl Gene ENSMUSG00000025330
Encoded Proteins
peptidyl arginine deiminase, type IV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Padi4 plays a role in chromatin decondensation to form neutrophil extracellular traps (NETs) in an innate immune response to bacterial infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159339:
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:140745865-140774236
Strand Reverse strand
Band D3
Transcripts
ENSMUST00000026381 ENSMUSP00000026381
ENSMUST00000137516
ENSMUST00000143019
ENSMUST00000137440
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016990 arginine deiminase activity
Biological Process
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
GO:0018101 protein citrullination
GO:0019827 stem cell maintenance
GO:0036413 histone H3-R26 citrullination
GO:0036414 histone citrullination
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.250358
RefSeq NM_011061 XM_006534677 XM_006538633
OMIM
CCDS CCDS18854
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas