Version 5.4
Bos taurus Gene: PADI4
Summary
InnateDB Gene IDBG-645799.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PADI4
Gene Name protein-arginine deiminase type-4
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000012052
Encoded Proteins
IDBP-698550
peptidyl arginine deiminase, type IV
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20733033
[Mus musculus] Padi4 plays a role in chromatin decondensation to form neutrophil extracellular traps (NETs) in an innate immune response to bacterial infection.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159339:
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:135836956-135864707
Strand Reverse strand
Band
Transcripts
ENSBTAT00000015991 ENSBTAP00000015991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004668 protein-arginine deiminase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0016990 arginine deiminase activity
Biological Process
GO:0006334 nucleosome assembly
GO:0006338 chromatin remodeling
GO:0006464 cellular protein modification process
GO:0016568 chromatin modification
GO:0018101 protein citrullination
GO:0019827 stem cell maintenance
GO:0036413 histone H3-R26 citrullination
GO:0036414 histone citrullination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000159339
View Gene Order
ENSMUSG00000025330
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.48485
RefSeq NM_001192173 XM_005203091
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca