InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rab6a

Summary

InnateDB Gene

IDBG-201562.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rab6a

Gene Name

RAB6A, member RAS oncogene family

Synonyms

2610028L11Rik; AA419671; Rab6

Species

Mus musculus

Ensembl Gene

ENSMUSG00000030704

Encoded Proteins

IDBP-201564

RAB6, member RAS oncogene family

IDBP-201566

RAB6, member RAS oncogene family

IDBP-267490

RAB6, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175582:
This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:100607410-100641268

Strand

Forward strand

Band

Transcripts

ENSMUST00000098252	ENSMUSP00000095852
ENSMUST00000032946	ENSMUSP00000032946
ENSMUST00000107048	ENSMUSP00000102663
ENSMUST00000123960

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001671	ATPase activator activity
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0051117	ATPase binding

Biological Process

GO:0000042	protein targeting to Golgi
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0018125	peptidyl-cysteine methylation
GO:0032781	positive regulation of ATPase activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000175582

View Gene Order

ENSBTAG00000000025

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118798

Pre-NOTCH Processing in Golgi pathway

REACT_118744

Pre-NOTCH Expression and Processing pathway

REACT_111102

Signal Transduction pathway

REACT_299

Signaling by NOTCH pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.28650 Mm.473839 Mm.474075

RefSeq

NM_001163663 NM_024287

OMIM

CCDS

CCDS21503 CCDS52323

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas