Version 5.4
Homo sapiens Gene: RAB6A
Summary
InnateDB Gene IDBG-63894.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB6A
Gene Name RAB6A, member RAS oncogene family
Synonyms RAB6
Species Homo sapiens
Ensembl Gene ENSG00000175582
Encoded Proteins
IDBP-63896
RAB6A, member RAS oncogene family
IDBP-63898
RAB6A, member RAS oncogene family
IDBP-228180
RAB6A, member RAS oncogene family
IDBP-586551
RAB6A, member RAS oncogene family
IDBP-593815
RAB6A, member RAS oncogene family
IDBP-600144
RAB6A, member RAS oncogene family
IDBP-593195
RAB6A, member RAS oncogene family
IDBP-590408
RAB6A, member RAS oncogene family
IDBP-585596
RAB6A, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:73675638-73761137
Strand Reverse strand
Band q13.4
Transcripts
ENST00000336083 ENSP00000336850
ENST00000310653 ENSP00000311449
ENST00000400470 ENSP00000383318
ENST00000541973 ENSP00000443782
ENST00000541588 ENSP00000445350
ENST00000545625 ENSP00000440469
ENST00000540771 ENSP00000438842
ENST00000537446 ENSP00000443470
ENST00000541795
ENST00000536566 ENSP00000437863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000042 protein targeting to Golgi
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0018125 peptidyl-cysteine methylation
GO:0019882 antigen processing and presentation
GO:0034067 protein localization to Golgi apparatus
GO:0072385 minus-end-directed organelle transport along microtubule
Cellular Component
GO:0000139 Golgi membrane
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0016020 membrane
GO:0031410 cytoplasmic vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030704
View Gene Order
ENSBTAG00000000025
Not yet available
Pathways
NETPATH
REACTOME
REACT_118798
Pre-NOTCH Processing in Golgi pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_111102
Signal Transduction pathway
REACT_299
Signaling by NOTCH pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.503222
RefSeq NM_001077637 NM_001243718 NM_001243719 NM_002869 NM_198896
HUGO
OMIM
CCDS CCDS58155 CCDS58156 CCDS8223 CCDS8224
HPRD 01543
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca