Version 5.4
Homo sapiens Gene: WARS
Summary
InnateDB Gene IDBG-20170.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WARS
Gene Name tryptophanyl-tRNA synthetase
Synonyms GAMMA-2; IFI53; IFP53
Species Homo sapiens
Ensembl Gene ENSG00000140105
Encoded Proteins
IDBP-20172
tryptophanyl-tRNA synthetase
IDBP-20174
tryptophanyl-tRNA synthetase
IDBP-20176
tryptophanyl-tRNA synthetase
IDBP-244714
tryptophanyl-tRNA synthetase
IDBP-598723
tryptophanyl-tRNA synthetase
IDBP-599954
tryptophanyl-tRNA synthetase
IDBP-601660
tryptophanyl-tRNA synthetase
IDBP-595461
tryptophanyl-tRNA synthetase
IDBP-603005
tryptophanyl-tRNA synthetase
IDBP-594384
tryptophanyl-tRNA synthetase
IDBP-602037
tryptophanyl-tRNA synthetase
IDBP-594222
tryptophanyl-tRNA synthetase
IDBP-596566
tryptophanyl-tRNA synthetase
IDBP-597417
tryptophanyl-tRNA synthetase
IDBP-602373
tryptophanyl-tRNA synthetase
IDBP-595609
tryptophanyl-tRNA synthetase
IDBP-596875
tryptophanyl-tRNA synthetase
IDBP-594409
tryptophanyl-tRNA synthetase
IDBP-597929
tryptophanyl-tRNA synthetase
IDBP-595191
tryptophanyl-tRNA synthetase
IDBP-594970
tryptophanyl-tRNA synthetase
IDBP-592483
tryptophanyl-tRNA synthetase
IDBP-601104
tryptophanyl-tRNA synthetase
IDBP-596624
tryptophanyl-tRNA synthetase
IDBP-598524
tryptophanyl-tRNA synthetase
IDBP-585281
tryptophanyl-tRNA synthetase
IDBP-599427
tryptophanyl-tRNA synthetase
IDBP-592302
tryptophanyl-tRNA synthetase
IDBP-599842
tryptophanyl-tRNA synthetase
IDBP-598740
tryptophanyl-tRNA synthetase
IDBP-600473
tryptophanyl-tRNA synthetase
IDBP-598819
tryptophanyl-tRNA synthetase
IDBP-599381
tryptophanyl-tRNA synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. Tryptophanyl-tRNA synthetase (WARS) catalyzes the aminoacylation of tRNA(trp) with tryptophan and is induced by interferon. Tryptophanyl-tRNA synthetase belongs to the class I tRNA synthetase family. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:100333788-100376805
Strand Reverse strand
Band q32.2
Transcripts
ENST00000355338 ENSP00000347495
ENST00000358655 ENSP00000351481
ENST00000344102 ENSP00000339485
ENST00000392882 ENSP00000376620
ENST00000557135 ENSP00000451460
ENST00000556645 ENSP00000451887
ENST00000554950
ENST00000557614
ENST00000554601 ENSP00000451891
ENST00000553395 ENSP00000451490
ENST00000556504 ENSP00000451251
ENST00000554084
ENST00000557722 ENSP00000450500
ENST00000557297 ENSP00000451599
ENST00000556435 ENSP00000452519
ENST00000553808
ENST00000554331
ENST00000555063
ENST00000556338 ENSP00000451544
ENST00000556698 ENSP00000450427
ENST00000557239
ENST00000553524 ENSP00000451349
ENST00000555410 ENSP00000450934
ENST00000556579
ENST00000554772 ENSP00000451469
ENST00000556660 ENSP00000451402
ENST00000556783 ENSP00000451679
ENST00000553413 ENSP00000452550
ENST00000553769 ENSP00000451906
ENST00000557094
ENST00000553545 ENSP00000451716
ENST00000554820 ENSP00000450563
ENST00000557347 ENSP00000451922
ENST00000554509 ENSP00000451894
ENST00000556209 ENSP00000451027
ENST00000554605 ENSP00000450978
ENST00000555813 ENSP00000451953
ENST00000556695 ENSP00000451777
ENST00000556295 ENSP00000451377
ENST00000555031 ENSP00000450623
ENST00000553934 ENSP00000452379
ENST00000553581 ENSP00000452358
ENST00000555464
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 42 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0001525 angiogenesis
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0045765 regulation of angiogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021266
View Gene Order
ENSBTAG00000004679
Not yet available
Pathways
NETPATH
REACTOME
REACT_15306
Cytosolic tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00970
Aminoacyl-tRNA biosynthesis pathway
INOH
INOH website
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL G3V2C0 G3V2F2 G3V313 G3V339 G3V3R3 G3V3S7 G3V3X0 G3V4C7 G3V4N8 G3V4S4 G3V5H5 G3V5W1 P78534
UniProt Splice Variant
Entrez Gene 7453
UniGene Hs.497599 Hs.736264
RefSeq NM_004184 NM_173701 NM_213645 NM_213646 XM_005268044 XM_006720249
HUGO HGNC:12729
OMIM 191050
CCDS CCDS9960 CCDS9961
HPRD 01845
IMGT
EMBL AL135838 AL157871 S82904
GenPept AAB39380
RNA Seq Atlas 7453

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca