Version 5.4
Mus musculus Gene: Nrxn1
Summary
InnateDB Gene IDBG-201803.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nrxn1
Gene Name neurexin I
Synonyms 1700062G21Rik; 9330127H16Rik; A230068P09Rik; mKIAA0578
Species Mus musculus
Ensembl Gene ENSMUSG00000024109
Encoded Proteins
IDBP-201805
neurexin I
IDBP-201807
neurexin I
IDBP-531789
neurexin I
IDBP-536845
neurexin I
IDBP-541513
neurexin I
IDBP-534517
neurexin I
IDBP-622710
neurexin I
IDBP-622712
neurexin I
IDBP-622714
neurexin I
IDBP-622716
neurexin I
IDBP-714927
IDBP-715590
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179915:
Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:90033644-91092805
Strand Reverse strand
Band E5
Transcripts
ENSMUST00000054059 ENSMUSP00000057294
ENSMUST00000072671 ENSMUSP00000072458
ENSMUST00000160844 ENSMUSP00000125407
ENSMUST00000159778 ENSMUSP00000125561
ENSMUST00000161402 ENSMUSP00000124116
ENSMUST00000160800 ENSMUSP00000124561
ENSMUST00000161102
ENSMUST00000161637
ENSMUST00000162227
ENSMUST00000160467
ENSMUST00000159419
ENSMUST00000162002
ENSMUST00000173222
ENSMUST00000173917 ENSMUSP00000133389
ENSMUST00000174337 ENSMUSP00000133724
ENSMUST00000172466 ENSMUSP00000134402
ENSMUST00000174331 ENSMUSP00000133491
ENSMUST00000177342 ENSMUSP00000135301
ENSMUST00000176118 ENSMUSP00000135241
ENSMUST00000176918
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005246 calcium channel regulator activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0033130 acetylcholine receptor binding
GO:0046872 metal ion binding
GO:0048306 calcium-dependent protein binding
GO:0050839 cell adhesion molecule binding
GO:0097109 neuroligin family protein binding
Biological Process
GO:0001525 angiogenesis
GO:0007155 cell adhesion
GO:0007157 heterophilic cell-cell adhesion
GO:0007158 neuron cell-cell adhesion
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0007416 synapse assembly
GO:0007612 learning
GO:0016339 calcium-dependent cell-cell adhesion
GO:0021707 cerebellar granule cell differentiation
GO:0030534 adult behavior
GO:0035176 social behavior
GO:0035418 protein localization to synapse
GO:0042297 vocal learning
GO:0042551 neuron maturation
GO:0045184 establishment of protein localization
GO:0050885 neuromuscular process controlling balance
GO:0051490 negative regulation of filopodium assembly
GO:0051965 positive regulation of synapse assembly
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0060134 prepulse inhibition
GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0071625 vocalization behavior
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090129 positive regulation of synapse maturation
GO:0097091 synaptic vesicle clustering
GO:0097104 postsynaptic membrane assembly
GO:0097105 presynaptic membrane assembly
GO:0097112 gamma-aminobutyric acid receptor clustering
GO:0097114 N-methyl-D-aspartate receptor clustering
GO:0097116 gephyrin clustering
GO:0097117 guanylate kinase-associated protein clustering
GO:0097118 neuroligin clustering
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000821 regulation of grooming behavior
Cellular Component
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0042734 presynaptic membrane
GO:0044295 axonal growth cone
GO:0060076 excitatory synapse
GO:0060077 inhibitory synapse
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000179915
View Gene Order
Pathways
NETPATH
REACTOME
REACT_206066
Extracellular matrix organization pathway
REACT_196607
Non-integrin membrane-ECM interactions pathway
KEGG
mmu04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_118779
Extracellular matrix organization pathway
REACT_163874
Non-integrin membrane-ECM interactions pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
Cross-References
SwissProt Q9CS84
TrEMBL
UniProt Splice Variant
Entrez Gene 18189
UniGene Mm.312068
RefSeq NM_020252 NM_177284 XM_006523806 XM_006523812
OMIM
CCDS CCDS57112 CCDS57113
HPRD
IMGT
MGI ID MGI:1096391
MGI Symbol Nrxn1
EMBL AB093249 AC101872 AC131326 AC151286 AC154325 AC154599 AC167814 AC170901 AC171209 AF387674 AJ006802 AK017578 BC047146 CT025708 CT486002
GenPept AAH47146 AAK70469 AAK70470 AAK70471 BAB30815 BAC41433 CAA07257
RNA Seq Atlas 18189

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca