Version 5.4
Homo sapiens Gene: HOPX
Summary
InnateDB Gene IDBG-20189.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOPX
Gene Name HOP homeobox
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171476
Encoded Proteins
IDBP-20191
HOP homeobox
IDBP-20195
HOP homeobox
IDBP-20197
HOP homeobox
IDBP-20199
HOP homeobox
IDBP-368624
HOP homeobox
IDBP-478886
HOP homeobox
IDBP-475813
HOP homeobox
IDBP-601832
HOP homeobox
IDBP-598413
HOP homeobox
IDBP-583220
HOP homeobox
IDBP-599035
HOP homeobox
IDBP-598162
HOP homeobox
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:56647988-56681899
Strand Reverse strand
Band q12
Transcripts
ENST00000381260 ENSP00000370659
ENST00000381255 ENSP00000370654
ENST00000337881 ENSP00000337330
ENST00000317745 ENSP00000315198
ENST00000420433 ENSP00000396275
ENST00000508121 ENSP00000422175
ENST00000503864
ENST00000503639 ENSP00000424101
ENST00000506661
ENST00000556376 ENSP00000451794
ENST00000553379 ENSP00000452340
ENST00000555760 ENSP00000452098
ENST00000556614 ENSP00000452003
ENST00000554144 ENSP00000450527
ENST00000605395
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0008016 regulation of heart contraction
GO:0016575 histone deacetylation
GO:0043393 regulation of protein binding
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0045596 negative regulation of cell differentiation
GO:0048286 lung alveolus development
GO:0051155 positive regulation of striated muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000059325
View Gene Order
ENSBTAG00000002333
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9BPY8
TrEMBL
UniProt Splice Variant
Entrez Gene 84525
UniGene Hs.619396
RefSeq NM_001145459 NM_001145460 NM_032495 NM_139211 NM_139212 XM_006714052 XM_006714053
HUGO HGNC:24961
OMIM 607275
CCDS CCDS3507 CCDS47062 CCDS54767
HPRD 06280
IMGT
EMBL AB059408 AB059409 AB059410 AC108215 AF454763 AF492675 AF492676 AF492677 AF492678 AF492679 AF492680 AF492681 AK289707 BC014225
GenPept AAH14225 AAL56613 AAM46827 AAM46828 AAM46829 AAM46830 AAM46831 AAM46832 AAM46833 BAB40926 BAB40927 BAB40928 BAF82396
RNA Seq Atlas 84525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca