Version 5.4
Bos taurus Gene: HOP
Summary
InnateDB Gene IDBG-642587.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HOP
Gene Name Homeodomain-only protein
Synonyms HOP; LAGY
Species Bos taurus
Ensembl Gene ENSBTAG00000002333
Encoded Proteins
IDBP-695051
Homeodomain-only protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171476:
The protein encoded by this gene is a homeodomain protein that lacks certain conserved residues required for DNA binding. It was reported that choriocarcinoma cell lines and tissues failed to express this gene, which suggested the possible involvement of this gene in malignant conversion of placental trophoblasts. Studies in mice suggest that this protein may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development. Multiple alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:73639370-73648429
Strand Reverse strand
Band
Transcripts
ENSBTAT00000003013 ENSBTAP00000003013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001829 trophectodermal cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0007507 heart development
GO:0008016 regulation of heart contraction
GO:0016575 histone deacetylation
GO:0043393 regulation of protein binding
GO:0043415 positive regulation of skeletal muscle tissue regeneration
GO:0045596 negative regulation of cell differentiation
GO:0048286 lung alveolus development
GO:0051155 positive regulation of striated muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000171476
View Gene Order
ENSMUSG00000059325
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt Q8MJD5
TrEMBL
UniProt Splice Variant
Entrez Gene 281270
UniGene
RefSeq NM_174097 XM_005207940 XM_005207941 XM_005207942 XM_005207943
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF492683 BC102635
GenPept AAI02636 AAM46835
RNA Seq Atlas 281270

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca