InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Nup98

Summary

InnateDB Gene

IDBG-202647.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nup98

Gene Name

nucleoporin 98

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000063550

Encoded Proteins

IDBP-202651

nucleoporin 98

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110713:
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:102134204-102210120

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070165

ENSMUSP00000068530

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	30 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017056	structural constituent of nuclear pore
GO:0042277	peptide binding

Biological Process

GO:0000059	protein import into nucleus, docking
GO:0006260	DNA replication
GO:0006810	transport
GO:0051028	mRNA transport
GO:0051292	nuclear pore complex assembly

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0031965	nuclear membrane
GO:0034399	nuclear periphery
GO:0042405	nuclear inclusion body
GO:0044615	nuclear pore nuclear basket