Bos taurus Gene: NUP98
InnateDB Gene IDBG-634720.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP98
Gene Name Uncharacterized protein
Species Bos taurus
Ensembl Gene ENSBTAG00000008432
Encoded Proteins
nucleoporin 98kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110713:
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:52097535-52183246
Strand Forward strand
ENSBTAT00000011092 ENSBTAP00000011092
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Predicted by orthology
Total 40 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0017056 structural constituent of nuclear pore
Biological Process
GO:0006260 DNA replication
GO:0006810 transport
GO:0051292 nuclear pore complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
GO:0042405 nuclear inclusion body
GO:0044615 nuclear pore nuclear basket
Homo sapiens
Mus musculus
Gene ID
Gene Order
Pathway Predictions based on Human Orthology Data
Nuclear Envelope Breakdown pathway
Cell Cycle, Mitotic pathway
Disease pathway
Nuclear Pore Complex (NPC) Disassembly pathway
Separation of Sister Chromatids pathway
SLC-mediated transmembrane transport pathway
Resolution of Sister Chromatid Cohesion pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
Cell Cycle pathway
Metabolism pathway
M Phase pathway
Transcriptional regulation by small RNAs pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Prometaphase pathway
Glucose transport pathway
Transmembrane transport of small molecules pathway
Hexose transport pathway
Glycogen storage diseases pathway
Gene Expression pathway
Regulatory RNA pathways pathway
Mitotic Prophase pathway
Myoclonic epilepsy of Lafora pathway
Mitotic Anaphase pathway
Metabolism of carbohydrates pathway
RNA transport pathway
RNA transport pathway
UniProt Splice Variant
Entrez Gene 540004
UniGene Bt.104229 Bt.110350
RefSeq XM_005194640 XM_005216208
EMBL DAAA02040991
RNA Seq Atlas 540004