Homo sapiens Gene: STX1A
Summary
InnateDB Gene IDBG-20282.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX1A
Gene Name syntaxin 1A (brain)
Synonyms HPC-1; P35-1; STX1; SYN1A;
Species Homo sapiens
Ensembl Gene ENSG00000106089
Encoded Proteins
syntaxin 1A (brain)
syntaxin 1A (brain)
syntaxin 1A (brain)
syntaxin 1A (brain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:73699206-73719672
Strand Reverse strand
Band q11.23
Transcripts
ENST00000222812 ENSP00000222812
ENST00000395156 ENSP00000378585
ENST00000395155 ENSP00000378584
ENST00000395154 ENSP00000378583
ENST00000484736
ENST00000480126
ENST00000491645
ENST00000497980
ENST00000491427
ENST00000496216
ENST00000461441
ENST00000470878
ENST00000494245
ENST00000462135
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0001948 glycoprotein binding
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0019855 calcium channel inhibitor activity
GO:0019904 protein domain specific binding
GO:0030674 protein binding, bridging
GO:0032028 myosin head/neck binding
GO:0043008 ATP-dependent protein binding
GO:0046982 protein heterodimerization activity
GO:0047485 protein N-terminus binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0001956 positive regulation of neurotransmitter secretion
GO:0006112 energy reserve metabolic process
GO:0006886 intracellular protein transport
GO:0007268 synaptic transmission
GO:0007269 neurotransmitter secretion
GO:0009629 response to gravity
GO:0014047 glutamate secretion
GO:0016081 synaptic vesicle docking involved in exocytosis
GO:0016192 vesicle-mediated transport
GO:0017156 calcium ion-dependent exocytosis
GO:0017157 regulation of exocytosis
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045921 positive regulation of exocytosis
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0008021 synaptic vesicle
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0030141 secretory granule
GO:0030672 synaptic vesicle membrane
GO:0031201 SNARE complex
GO:0042641 actomyosin
GO:0043005 neuron projection
GO:0043229 intracellular organelle
GO:0043234 protein complex
GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Acetylcholine Neurotransmitter Release Cycle pathway
Neuronal System pathway
Serotonin Neurotransmitter Release Cycle pathway
Uptake and actions of bacterial toxins pathway
Neurotoxicity of clostridium toxins pathway
Norepinephrine Neurotransmitter Release Cycle pathway
GABA synthesis, release, reuptake and degradation pathway
Metabolism of proteins pathway
Insulin processing pathway
Transmission across Chemical Synapses pathway
Neurotransmitter Release Cycle pathway
Dopamine Neurotransmitter Release Cycle pathway
Regulation of insulin secretion pathway
Metabolism pathway
Peptide hormone metabolism pathway
Glutamate Neurotransmitter Release Cycle pathway
Disease pathway
Toxicity of botulinum toxin type C (BoNT/C) pathway
KEGG
SNARE interactions in vesicular transport pathway
INOH
PID BIOCARTA
PID NCI
Effects of Botulinum toxin
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647024
RefSeq NM_001165903 NM_004603 XM_005250552
HUGO
OMIM
CCDS CCDS34655 CCDS55120
HPRD 01721
IMGT
EMBL
GenPept
RNA Seq Atlas