InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STX1A

Summary

InnateDB Protein

IDBP-240118.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STX1A

Protein Name

syntaxin 1A (brain)

Synonyms

HPC-1; P35-1; STX1; SYN1A;

Species

Homo sapiens

Ensembl Protein

ENSP00000378585

InnateDB Gene

IDBG-20282 (STX1A)

Protein Structure

UniProt Annotation

Function

Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}.Isoform 2: Secreted {ECO:0000305}.

Disease Associations

Note=STX1A is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Tissue Specificity

Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain. {ECO:0000269PubMed:10644452}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	66 [view]
Protein-Protein	66 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005484	SNAP receptor activity
GO:0005515	protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006886	intracellular protein transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0014047	glutamate secretion
GO:0016192	vesicle-mediated transport
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0043005	neuron projection