InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdcd6ip

Summary

InnateDB Gene

IDBG-203055.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdcd6ip

Gene Name

programmed cell death 6 interacting protein

Synonyms

AI480591; Aip1; Alix; AW544830; C76364; Eig2; mKIAA1375

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032504

Encoded Proteins

IDBP-203057

programmed cell death 6 interacting protein

IDBP-257227

programmed cell death 6 interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170248:
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:113651744-113708259

Strand

Reverse strand

Band

Transcripts

ENSMUST00000035086	ENSMUSP00000035086
ENSMUST00000111861	ENSMUSP00000107492
ENSMUST00000142256
ENSMUST00000137104
ENSMUST00000135545
ENSMUST00000156425

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 72 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	72 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0015031	protein transport
GO:0051301	cell division

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000170248

View Gene Order

ENSBTAG00000017426

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu04144

Endocytosis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_228211

Uptake and actions of bacterial toxins pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_228255

Uptake and function of anthrax toxins pathway

REACT_116125

Disease pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.29816 Mm.397769

RefSeq

NM_001164677 NM_001164678 NM_011052

OMIM

CCDS

CCDS23588 CCDS52947

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas