InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDCD6IP

Summary

InnateDB Gene

IDBG-24373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDCD6IP

Gene Name

programmed cell death 6 interacting protein

Synonyms

AIP1; ALIX; DRIP4; HP95

Species

Homo sapiens

Ensembl Gene

ENSG00000170248

Encoded Proteins

IDBP-24375

programmed cell death 6 interacting protein

IDBP-370412

programmed cell death 6 interacting protein

IDBP-370414

programmed cell death 6 interacting protein

IDBP-370418

programmed cell death 6 interacting protein

IDBP-370420

programmed cell death 6 interacting protein

IDBP-370424

programmed cell death 6 interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:33798352-33869707

Strand

Forward strand

Band

p22.3

Transcripts

ENST00000307296	ENSP00000307387
ENST00000457054	ENSP00000411825
ENST00000435909	ENSP00000393777
ENST00000430877	ENSP00000398895
ENST00000413073	ENSP00000406693
ENST00000412887	ENSP00000415150
ENST00000477798
ENST00000498147
ENST00000484478
ENST00000494810
ENST00000459659
ENST00000482561
ENST00000487821
ENST00000465122
ENST00000495235
ENST00000489869
ENST00000473593

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 112 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	112 [view]
Protein-Protein	111 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0042803	protein homodimerization activity
GO:0046983	protein dimerization activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0015031	protein transport
GO:0016032	viral process
GO:0019058	viral life cycle
GO:0051301	cell division

Cellular Component

GO:0001772	immunological synapse
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000032504

View Gene Order

ENSBTAG00000017426

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

REACT_6361

Late Phase of HIV Life Cycle pathway

REACT_228211

Uptake and actions of bacterial toxins pathway

REACT_6256

HIV Life Cycle pathway

REACT_6185

HIV Infection pathway

REACT_6359

Budding and maturation of HIV virion pathway

REACT_228255

Uptake and function of anthrax toxins pathway

REACT_116125

Disease pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.475896 Hs.595926 Hs.611958 Hs.646405

RefSeq

NM_001162429 NM_013374

HUGO

OMIM

CCDS

CCDS2660 CCDS54561

HPRD

06425

IMGT

EMBL

GenPept

RNA Seq Atlas