InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rgs4

Summary

InnateDB Gene

IDBG-203529.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs4

Gene Name

regulator of G-protein signaling 4

Synonyms

AA004315; AA597169; ESTM48; ESTM50

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038530

Encoded Proteins

IDBP-203531

regulator of G-protein signaling 4

IDBP-258311

regulator of G-protein signaling 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000117152:
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37%% identical to RGS1 and 97%% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:169741477-169747642

Strand

Reverse strand

Band

H2.3

Transcripts

ENSMUST00000027991	ENSMUSP00000027991
ENSMUST00000111357	ENSMUSP00000106989
ENSMUST00000132567

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0005096	GTPase activator activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway