Version 5.4
Homo sapiens Gene: RGS4
Summary
InnateDB Gene IDBG-104428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS4
Gene Name regulator of G-protein signaling 4
Synonyms RGP4; SCZD9
Species Homo sapiens
Ensembl Gene ENSG00000117152
Encoded Proteins
IDBP-104430
regulator of G-protein signaling 4
IDBP-104432
regulator of G-protein signaling 4
IDBP-104434
regulator of G-protein signaling 4
IDBP-389446
regulator of G-protein signaling 4
IDBP-596288
regulator of G-protein signaling 4
IDBP-589513
regulator of G-protein signaling 4
IDBP-598600
regulator of G-protein signaling 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37%% identical to RGS1 and 97%% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:163068775-163076802
Strand Forward strand
Band q23.3
Transcripts
ENST00000367909 ENSP00000356885
ENST00000367908 ENSP00000356884
ENST00000367906 ENSP00000356882
ENST00000421743 ENSP00000397181
ENST00000491263
ENST00000527393
ENST00000531057 ENSP00000436106
ENST00000527809 ENSP00000433261
ENST00000533019
ENST00000528938 ENSP00000432194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 17 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0005096 GTPase activator activity
GO:0005516 calmodulin binding
Biological Process
GO:0000188 inactivation of MAPK activity
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038530
View Gene Order
ENSBTAG00000046277
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_19333
G alpha (z) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
INOH
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt P49798
TrEMBL E9PS05
UniProt Splice Variant
Entrez Gene 5999
UniGene Hs.386726 Hs.595206 Hs.714067
RefSeq NM_001102445 NM_001113380 NM_001113381 NM_005613
HUGO HGNC:10000
OMIM 602516
CCDS CCDS44272 CCDS1243 CCDS44270 CCDS44271
HPRD 03947
IMGT
EMBL AF493928 AK093959 AK295540 AK296240 AK312250 AL583850 BC000737 BC051869 BT007025 CH471067 DQ346662 DQ346663 DQ346664 EF054877 U27768
GenPept AAC50395 AAH00737 AAH51869 AAM12642 AAP35671 ABC94590 ABC94591 ABC94592 ABL74968 BAG35182 BAG58449 BAG58958 CAH73766 CAH73767 CAH73768 EAW90727 EAW90728
RNA Seq Atlas 5999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca