InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxo2

Summary

InnateDB Gene

IDBG-204294.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo2

Gene Name

F-box protein 2

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041556

Encoded Proteins

IDBP-204296

F-box protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116661:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:148160621-148166424

Strand

Forward strand

Band

Transcripts

ENSMUST00000047951

ENSMUSP00000037377

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006516	glycoprotein catabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031396	regulation of protein ubiquitination

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0031090	organelle membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000116661

View Gene Order

ENSBTAG00000007223

Not yet available

Pathways

NETPATH

REACTOME

REACT_236645

Class I MHC mediated antigen processing & presentation pathway

REACT_230745

Immune System pathway

REACT_199115

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_229531

Adaptive Immune System pathway

KEGG

mmu04120

Ubiquitin mediated proteolysis pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.262287

RefSeq

NM_176848 XM_006535939 XM_006538814

OMIM

CCDS

CCDS18935

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas