Mus musculus Gene: Fbxo2
Summary
InnateDB Gene IDBG-204294.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo2
Gene Name F-box protein 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041556
Encoded Proteins
F-box protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116661:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:148160621-148166424
Strand Forward strand
Band E2
Transcripts
ENSMUST00000047951 ENSMUSP00000037377
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 20 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001540 beta-amyloid binding
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006516 glycoprotein catabolic process
GO:0008285 negative regulation of cell proliferation
GO:0016567 protein ubiquitination
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031396 regulation of protein ubiquitination
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0031090 organelle membrane
GO:0043197 dendritic spine
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class I MHC mediated antigen processing & presentation pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
KEGG
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
Er associated degradation (erad) pathway [Biocarta view]
PID NCI
Cross-References
SwissProt Q80UW2
TrEMBL Q3USR5
UniProt Splice Variant
Entrez Gene 230904
UniGene Mm.262287
RefSeq NM_176848 XM_006535939 XM_006538814
OMIM
CCDS CCDS18935
HPRD
IMGT
MGI ID MGI:2446216
MGI Symbol Fbxo2
EMBL AK140175 BC027053 BC046586
GenPept AAH27053 AAH46586 BAE24266
RNA Seq Atlas 230904