InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo2

Summary

InnateDB Protein

IDBP-204296.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo2

Protein Name

F-box protein 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037377

InnateDB Gene

IDBG-204294 (Fbxo2)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. {ECO:0000269PubMed:12140560, ECO:0000269PubMed:14990996, ECO:0000269PubMed:15723043, ECO:0000269PubMed:17215248, ECO:0000269PubMed:17720138}.

Subcellular Localization

Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Detected in brain and cochlea, in epithelial support cells and hair cells of the organ of Corti (at protein level). {ECO:0000269PubMed:17215248, ECO:0000269PubMed:17494702}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001540	beta-amyloid binding
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006516	glycoprotein catabolic process
GO:0008285	negative regulation of cell proliferation
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031396	regulation of protein ubiquitination

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0019005	SCF ubiquitin ligase complex
GO:0031090	organelle membrane
GO:0043197	dendritic spine
GO:0070062	extracellular vesicular exosome