InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Trpm7

Summary

InnateDB Gene

IDBG-204376.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpm7

Gene Name

transient receptor potential cation channel, subfamily M, member 7

Synonyms

2310022G15Rik; 4833414K03Rik; 5033407O22Rik; CHAK; CHAK1; Ltpr7; LTrpC-7; Ltrpc7; TRPPLIK

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027365

Encoded Proteins

IDBP-204378

transient receptor potential cation channel, subfamily M, member 7

IDBP-204380

transient receptor potential cation channel, subfamily M, member 7

IDBP-539342

transient receptor potential cation channel, subfamily M, member 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092439:
The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam.[provided by RefSeq, May 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:126791565-126876230

Strand

Reverse strand

Band

Transcripts

ENSMUST00000103224	ENSMUSP00000099513
ENSMUST00000028843	ENSMUSP00000028843
ENSMUST00000127277
ENSMUST00000155675
ENSMUST00000136964	ENSMUSP00000119232
ENSMUST00000135733
ENSMUST00000125327
ENSMUST00000142334
ENSMUST00000132003
ENSMUST00000134408
ENSMUST00000152615

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004674	protein serine/threonine kinase activity
GO:0005216	ion channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017022	myosin binding
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0016340	calcium-dependent cell-matrix adhesion
GO:0031032	actomyosin structure organization
GO:0046777	protein autophosphorylation
GO:0055085	transmembrane transport
GO:0070266	necroptotic process
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0001726	ruffle
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000092439

View Gene Order

ENSBTAG00000031165

Not yet available

Pathways

NETPATH

REACTOME

REACT_196640

Stimuli-sensing channels pathway

REACT_262350

Ion channel transport pathway

REACT_253400

Transmembrane transport of small molecules pathway

REACT_227861

TRP channels pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_160189

Stimuli-sensing channels pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_25300

Ion channel transport pathway

REACT_169333

TRP channels pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.244705 Mm.406396 Mm.407674 Mm.416047

RefSeq

NM_001164325 NM_021450 XM_006499965

OMIM

CCDS

CCDS16689 CCDS50700

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas