InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rffl

Summary

InnateDB Gene

IDBG-204769.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rffl

Gene Name

ring finger and FYVE like domain containing protein

Synonyms

1700051E09Rik; 4930516L10Rik; BG080975; Carp2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020696

Encoded Proteins

IDBP-204771

ring finger and FYVE like domain containing protein

IDBP-204773

ring finger and FYVE like domain containing protein

IDBP-204775

ring finger and FYVE like domain containing protein

IDBP-204777

ring finger and FYVE like domain containing protein

IDBP-204779

ring finger and FYVE like domain containing protein

IDBP-265097

ring finger and FYVE like domain containing protein

IDBP-533787

ring finger and FYVE like domain containing protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000092871:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:82802449-82871210

Strand

Reverse strand

Band

Transcripts

ENSMUST00000093975	ENSMUSP00000091510
ENSMUST00000071152	ENSMUSP00000071150
ENSMUST00000074515	ENSMUSP00000074108
ENSMUST00000103218	ENSMUSP00000099507
ENSMUST00000021036	ENSMUSP00000021036
ENSMUST00000108173	ENSMUSP00000103808
ENSMUST00000126660	ENSMUSP00000115846

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0002039	p53 binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019901	protein kinase binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006886	intracellular protein transport
GO:0010762	regulation of fibroblast migration
GO:0010804	negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936	protein K48-linked ubiquitination
GO:1901797	negative regulation of signal transduction by p53 class mediator
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Cellular Component

GO:0002947	tumor necrosis factor receptor superfamily complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0055038	recycling endosome membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000092871

View Gene Order

ENSBTAG00000013645

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_9

TNFalpha pathway

REACTOME

KEGG

INOH

PID NCI

tnfpathway

TNF receptor signaling pathway

Cross-References

SwissProt

Q6ZQM0

TrEMBL

Q3UD78 Q6YAT5 Q6YAT6

UniProt Splice Variant

Entrez Gene

67338

UniGene

Mm.341608

RefSeq

NM_001164570 XM_006533986 NM_001007465 NM_001164569 NM_001164571 NM_026097 XM_006533988 XM_006533989 XM_006533990

OMIM

CCDS

CCDS48867 CCDS25148 CCDS25149 CCDS48868

HPRD

IMGT

MGI ID

MGI:1914588

MGI Symbol

Rffl

EMBL

AF434814 AK007189 AK015806 AK028095 AK128983 AK150213 AL645594 AY163902 AY163903

GenPept

AAL30769 AAO42677 AAO42678 BAB24891 BAB29984 BAC25744 BAC87665 BAE29383 CAI25096 CAI25097 CAI25098

RNA Seq Atlas

67338