Homo sapiens Gene: RFFL
Summary
InnateDB Gene IDBG-41038.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFFL
Gene Name ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000092871
Encoded Proteins
ring finger and FYVE-like domain containing 1
ring finger and FYVE-like domain containing 1
ring finger and FYVE-like domain containing 1
ring finger and FYVE-like domain containing 1
ring finger and FYVE-like domain containing 1
ring finger and FYVE-like domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35005990-35089319
Strand Reverse strand
Band q12
Transcripts
ENST00000315249 ENSP00000326170
ENST00000394597 ENSP00000378096
ENST00000413582 ENSP00000408513
ENST00000415395 ENSP00000412322
ENST00000414419 ENSP00000395090
ENST00000447669 ENSP00000389832
ENST00000582308 ENSP00000462499
ENST00000580569
ENST00000581265 ENSP00000464000
ENST00000584655 ENSP00000463035
ENST00000581039 ENSP00000462656
ENST00000584541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006886 intracellular protein transport
GO:0010762 regulation of fibroblast migration
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032006 regulation of TOR signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular Component
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
TNFalpha pathway
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
TNF receptor signaling pathway
Cross-References
SwissProt Q8WZ73
TrEMBL C9JE27 J3KSI3 J3QR17
UniProt Splice Variant
Entrez Gene 117584
UniGene Hs.13680 Hs.556108 Hs.619546
RefSeq NM_001017368
HUGO HGNC:24821
OMIM 609735
CCDS CCDS11286
HPRD
IMGT
EMBL AC004223 AF434816 AK093112 AY098935 BC015681 BC028424 CH471147 CR933651
GenPept AAH15681 AAH28424 AAL30771 AAM29181 BAC04059 CAI45952 EAW80172 EAW80173 EAW80176 EAW80177 EAW80178
RNA Seq Atlas 117584