Version 5.4
Homo sapiens Gene: RFFL
Summary
InnateDB Gene IDBG-41038.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RFFL
Gene Name ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000092871
Encoded Proteins
IDBP-41042
ring finger and FYVE-like domain containing 1
IDBP-241266
ring finger and FYVE-like domain containing 1
IDBP-375390
ring finger and FYVE-like domain containing 1
IDBP-375391
ring finger and FYVE-like domain containing 1
IDBP-375392
ring finger and FYVE-like domain containing 1
IDBP-375393
ring finger and FYVE-like domain containing 1
IDBP-762383
IDBP-763764
IDBP-761296
IDBP-758227
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:35005990-35089319
Strand Reverse strand
Band q12
Transcripts
ENST00000315249 ENSP00000326170
ENST00000394597 ENSP00000378096
ENST00000413582 ENSP00000408513
ENST00000415395 ENSP00000412322
ENST00000414419 ENSP00000395090
ENST00000447669 ENSP00000389832
ENST00000582308 ENSP00000462499
ENST00000580569
ENST00000581265 ENSP00000464000
ENST00000584655 ENSP00000463035
ENST00000581039 ENSP00000462656
ENST00000584541
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0002039 p53 binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0019901 protein kinase binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006886 intracellular protein transport
GO:0010762 regulation of fibroblast migration
GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway
GO:0032006 regulation of TOR signaling
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
GO:1901797 negative regulation of signal transduction by p53 class mediator
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
Cellular Component
GO:0002947 tumor necrosis factor receptor superfamily complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020696
View Gene Order
ENSBTAG00000013645
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
tnfpathway
TNF receptor signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.13680 Hs.556108 Hs.619546
RefSeq NM_001017368
HUGO
OMIM
CCDS CCDS11286
HPRD 11489
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca