Homo sapiens Gene: EARS2
Summary
InnateDB Gene IDBG-20527.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EARS2
Gene Name glutamyl-tRNA synthetase 2, mitochondrial
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103356
Encoded Proteins
glutamyl-tRNA synthetase 2, mitochondrial (putative)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene belongs to the class-I aminoacyl-tRNA synthetase family and catalyzes the attachment of glutamate to tRNA(Glu). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:23522014-23557731
Strand Reverse strand
Band p12.2
Transcripts
ENST00000449606 ENSP00000395196
ENST00000564776
ENST00000561859
ENST00000564501 ENSP00000457107
ENST00000562799
ENST00000564987
ENST00000562402
ENST00000564759
ENST00000563232 ENSP00000456218
ENST00000564997 ENSP00000455875
ENST00000566017
ENST00000563459 ENSP00000456467
ENST00000562581 ENSP00000455519
ENST00000564461
ENST00000565344
ENST00000563499 ENSP00000458604
ENST00000564668 ENSP00000455789
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004818 glutamate-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0050561 glutamate-tRNA(Gln) ligase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006424 glutamyl-tRNA aminoacylation
GO:0010467 gene expression
GO:0043039 tRNA aminoacylation
GO:0070127 tRNA aminoacylation for mitochondrial protein translation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mitochondrial tRNA aminoacylation pathway
tRNA Aminoacylation pathway
Gene Expression pathway
KEGG
Porphyrin and chlorophyll metabolism pathway
Aminoacyl-tRNA biosynthesis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.620541 Hs.643812
RefSeq NM_001083614 XM_006721020
HUGO
OMIM
CCDS CCDS42132
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas