Mus musculus Gene: Pex12
Summary
InnateDB Gene IDBG-205311.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pex12
Gene Name peroxisomal biogenesis factor 12
Synonyms AI451906;
Species Mus musculus
Ensembl Gene ENSMUSG00000018733
Encoded Proteins
peroxisomal biogenesis factor 12
peroxisomal biogenesis factor 12
peroxisomal biogenesis factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000108733:
This gene belongs to the peroxin-12 family. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS). [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:83294642-83302586
Strand Reverse strand
Band C
Transcripts
ENSMUST00000018877 ENSMUSP00000018877
ENSMUST00000108146 ENSMUSP00000103781
ENSMUST00000153487
ENSMUST00000136369 ENSMUSP00000118829
ENSMUST00000176374 ENSMUSP00000134965
ENSMUST00000175741 ENSMUSP00000135145
ENSMUST00000176518 ENSMUSP00000135632
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008270 zinc ion binding
Biological Process
GO:0006625 protein targeting to peroxisome
GO:0007031 peroxisome organization
GO:0016558 protein import into peroxisome matrix
Cellular Component
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005779 integral component of peroxisomal membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Peroxisome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.102205 Mm.487983
RefSeq NM_134025 XM_006531913 XM_006531914 XM_006531915 XM_006531916
OMIM
CCDS CCDS25160
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas