Homo sapiens Gene: PPP2R5C
Summary
InnateDB Gene IDBG-20535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R5C
Gene Name protein phosphatase 2, regulatory subunit B', gamma
Synonyms B56G; PR61G;
Species Homo sapiens
Ensembl Gene ENSG00000078304
Encoded Proteins
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
protein phosphatase 2, regulatory subunit B', gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:101761798-101927989
Strand Forward strand
Band q32.31
Transcripts
ENST00000328724 ENSP00000329009
ENST00000334743 ENSP00000333905
ENST00000350249 ENSP00000262239
ENST00000445439 ENSP00000408389
ENST00000422945 ENSP00000412324
ENST00000556068
ENST00000554442 ENSP00000450525
ENST00000556260 ENSP00000454035
ENST00000557268 ENSP00000450931
ENST00000554504
ENST00000553890 ENSP00000452632
ENST00000553554 ENSP00000453875
ENST00000556086
ENST00000557621 ENSP00000450867
ENST00000556946 ENSP00000454124
ENST00000556307 ENSP00000452500
ENST00000553730
ENST00000557714 ENSP00000452630
ENST00000557095 ENSP00000451179
ENST00000556493
ENST00000553842
ENST00000556373
ENST00000556570
ENST00000554137 ENSP00000450743
ENST00000556218
ENST00000557534 ENSP00000452533
ENST00000557716 ENSP00000452124
ENST00000556805
ENST00000561006 ENSP00000453906
ENST00000555237 ENSP00000450816
ENST00000557071 ENSP00000450626
ENST00000554147
ENST00000607042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006508 proteolysis
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0016485 protein processing
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
truncated APC mutants destabilize the destruction complex pathway
Beta-catenin phosphorylation cascade pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Signaling by WNT in cancer pathway
AXIN missense mutants destabilize the destruction complex pathway
Signaling by Wnt pathway
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Signal Transduction pathway
Separation of Sister Chromatids pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Mitotic Prometaphase pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Platelet homeostasis pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Costimulation by the CD28 family pathway
Platelet sensitization by LDL pathway
CTLA4 inhibitory signaling pathway
Resolution of Sister Chromatid Cohesion pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Hemostasis pathway
Mitotic Metaphase and Anaphase pathway
KEGG
mRNA surveillance pathway pathway
Oocyte meiosis pathway
INOH
Insulin receptor signaling pathway
GPCR Dopamine D1like receptor signaling pathway pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 5527
UniGene Hs.368264 Hs.598749 Hs.613375 Hs.679341 Hs.733086
RefSeq NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587 XM_005267819 XM_005267820 XM_005267823 XM_005267826 XM_005267827
HUGO HGNC:9311
OMIM 601645
CCDS CCDS45163 CCDS53911 CCDS53912 CCDS9964 CCDS9965
HPRD 03385
IMGT
EMBL
GenPept
RNA Seq Atlas 5527