Version 5.4
Homo sapiens Gene: PPP2R5C
Summary
InnateDB Gene IDBG-20535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPP2R5C
Gene Name protein phosphatase 2, regulatory subunit B', gamma
Synonyms B56G; PR61G
Species Homo sapiens
Ensembl Gene ENSG00000078304
Encoded Proteins
IDBP-20537
protein phosphatase 2, regulatory subunit B', gamma
IDBP-20539
protein phosphatase 2, regulatory subunit B', gamma
IDBP-20541
protein phosphatase 2, regulatory subunit B', gamma
IDBP-377621
protein phosphatase 2, regulatory subunit B', gamma
IDBP-377622
protein phosphatase 2, regulatory subunit B', gamma
IDBP-585909
protein phosphatase 2, regulatory subunit B', gamma
IDBP-602903
protein phosphatase 2, regulatory subunit B', gamma
IDBP-599891
protein phosphatase 2, regulatory subunit B', gamma
IDBP-597842
protein phosphatase 2, regulatory subunit B', gamma
IDBP-594851
protein phosphatase 2, regulatory subunit B', gamma
IDBP-593677
protein phosphatase 2, regulatory subunit B', gamma
IDBP-585506
protein phosphatase 2, regulatory subunit B', gamma
IDBP-586929
protein phosphatase 2, regulatory subunit B', gamma
IDBP-598677
protein phosphatase 2, regulatory subunit B', gamma
IDBP-600331
protein phosphatase 2, regulatory subunit B', gamma
IDBP-602767
protein phosphatase 2, regulatory subunit B', gamma
IDBP-596310
protein phosphatase 2, regulatory subunit B', gamma
IDBP-599908
protein phosphatase 2, regulatory subunit B', gamma
IDBP-589572
protein phosphatase 2, regulatory subunit B', gamma
IDBP-589979
protein phosphatase 2, regulatory subunit B', gamma
IDBP-585354
protein phosphatase 2, regulatory subunit B', gamma
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:101761798-101927989
Strand Forward strand
Band q32.31
Transcripts
ENST00000328724 ENSP00000329009
ENST00000334743 ENSP00000333905
ENST00000350249 ENSP00000262239
ENST00000445439 ENSP00000408389
ENST00000422945 ENSP00000412324
ENST00000556068
ENST00000554442 ENSP00000450525
ENST00000556260 ENSP00000454035
ENST00000557268 ENSP00000450931
ENST00000554504
ENST00000553890 ENSP00000452632
ENST00000553554 ENSP00000453875
ENST00000556086
ENST00000557621 ENSP00000450867
ENST00000556946 ENSP00000454124
ENST00000556307 ENSP00000452500
ENST00000553730
ENST00000557714 ENSP00000452630
ENST00000557095 ENSP00000451179
ENST00000556493
ENST00000553842
ENST00000556373
ENST00000556570
ENST00000554137 ENSP00000450743
ENST00000556218
ENST00000557534 ENSP00000452533
ENST00000557716 ENSP00000452124
ENST00000556805
ENST00000561006 ENSP00000453906
ENST00000555237 ENSP00000450816
ENST00000557071 ENSP00000450626
ENST00000554147
ENST00000607042
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 44 [view]
Protein-Protein 44 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008601 protein phosphatase type 2A regulator activity
Biological Process
GO:0006508 proteolysis
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007165 signal transduction
GO:0008285 negative regulation of cell proliferation
GO:0016485 protein processing
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0050790 regulation of catalytic activity
Cellular Component
GO:0000159 protein phosphatase type 2A complex
GO:0000775 chromosome, centromeric region
GO:0005634 nucleus
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000017843
View Gene Order
ENSBTAG00000020192
Not yet available
Pathways
NETPATH
REACTOME
REACT_150425
Resolution of Sister Chromatid Cohesion pathway
REACT_682
Mitotic Prometaphase pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_19405
CTLA4 inhibitory signaling pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_23879
Platelet sensitization by LDL pathway
REACT_23876
Platelet homeostasis pathway
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_604
Hemostasis pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa04114
Oocyte meiosis pathway
hsa03015
mRNA surveillance pathway pathway
INOH
INOH website
Insulin receptor signaling pathway
INOH website
GPCR Dopamine D1like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL Q96B13
UniProt Splice Variant
Entrez Gene 5527
UniGene Hs.368264 Hs.598749 Hs.613375 Hs.679341 Hs.733086
RefSeq NM_001161725 NM_001161726 NM_002719 NM_178586 NM_178587 XM_005267819 XM_005267820 XM_005267823 XM_005267826 XM_005267827
HUGO HGNC:9311
OMIM 601645
CCDS CCDS45163 CCDS53911 CCDS53912 CCDS9964 CCDS9965
HPRD 03385
IMGT
EMBL AL118558 AL137779 BC016183
GenPept AAH16183
RNA Seq Atlas 5527

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca