Homo sapiens Gene: NDUFS4
Summary
InnateDB Gene IDBG-20547.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDUFS4
Gene Name NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Synonyms AQDQ; CI-18;
Species Homo sapiens
Ensembl Gene ENSG00000164258
Encoded Proteins
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:53560633-53683340
Strand Forward strand
Band q11.2
Transcripts
ENST00000296684 ENSP00000296684
ENST00000507026 ENSP00000424993
ENST00000502423 ENSP00000422177
ENST00000506974 ENSP00000425967
ENST00000506765 ENSP00000424570
ENST00000509443
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008137 NADH dehydrogenase (ubiquinone) activity
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0001932 regulation of protein phosphorylation
GO:0006120 mitochondrial electron transport, NADH to ubiquinone
GO:0007420 brain development
GO:0019933 cAMP-mediated signaling
GO:0022900 electron transport chain
GO:0022904 respiratory electron transport chain
GO:0032981 mitochondrial respiratory chain complex I assembly
GO:0044237 cellular metabolic process
GO:0044281 small molecule metabolic process
GO:0045333 cellular respiration
GO:0048146 positive regulation of fibroblast proliferation
GO:0051591 response to cAMP
GO:0072593 reactive oxygen species metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005747 mitochondrial respiratory chain complex I
GO:0045271 respiratory chain complex I
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Respiratory electron transport pathway
KEGG
Oxidative phosphorylation pathway
Alzheimer's disease pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6RI09
UniProt Splice Variant
Entrez Gene 4724
UniGene
RefSeq NM_002495 XM_005248525
HUGO HGNC:7711
OMIM 602694
CCDS CCDS3960
HPRD 04073
IMGT
EMBL AC008901 AC024569
GenPept
RNA Seq Atlas 4724