InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NDUFS4

Summary

InnateDB Gene

IDBG-629396.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDUFS4

Gene Name

NADH dehydrogenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003728

Encoded Proteins

IDBP-680795

NADH dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164258:
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), or NADH:ubiquinone oxidoreductase, the first multi-subunit enzyme complex of the mitochondrial respiratory chain. Complex I plays a vital role in cellular ATP production, the primary source of energy for many crucial processes in living cells. It removes electrons from NADH and passes them by a series of different protein-coupled redox centers to the electron acceptor ubiquinone. In well-coupled mitochondria, the electron flux leads to ATP generation via the building of a proton gradient across the inner membrane. Complex I is composed of at least 41 subunits, of which 7 are encoded by the mitochondrial genome and the remainder by nuclear genes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:25407689-25523382

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047463

ENSBTAP00000044670

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008137	NADH dehydrogenase (ubiquinone) activity
GO:0016651	oxidoreductase activity, acting on NAD(P)H

Biological Process

GO:0001932	regulation of protein phosphorylation
GO:0007420	brain development
GO:0019933	cAMP-mediated signaling
GO:0022900	electron transport chain
GO:0032981	mitochondrial respiratory chain complex I assembly
GO:0045333	cellular respiration
GO:0048146	positive regulation of fibroblast proliferation
GO:0051591	response to cAMP
GO:0055114	oxidation-reduction process
GO:0072593	reactive oxygen species metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005747	mitochondrial respiratory chain complex I
GO:0016020	membrane
GO:0070469	respiratory chain